6-tert-butyl 4a-methyl 1,3-diphenyl-1,4,4a,5,6,7-hexahydropyrido[4,3-c]pyridazine-4a,6-dicarboxylate

Base Information

• Chemical Name: 6-tert-butyl 4a-methyl 1,3-diphenyl-1,4,4a,5,6,7-hexahydropyrido[4,3-c]pyridazine-4a,6-dicarboxylate
• CAS No.: 1448863-46-4
• Molecular Formula: C₂₆H₂₉N₃O₄
• Molecular Weight: 447.534
• Mol file: 1448863-46-4.mol

Synonyms:

Chemical Property of 6-tert-butyl 4a-methyl 1,3-diphenyl-1,4,4a,5,6,7-hexahydropyrido[4,3-c]pyridazine-4a,6-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-tert-butyl 4a-methyl 1,3-diphenyl-1,4,4a,5,6,7-hexahydropyrido[4,3-c]pyridazine-4a,6-dicarboxylate

There total 2 articles about 6-tert-butyl 4a-methyl 1,3-diphenyl-1,4,4a,5,6,7-hexahydropyrido[4,3-c]pyridazine-4a,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

1-tert-butyl 3-methyl 4-oxo-3-(2-oxo-2-phenylethyl)piperidine-1,3-dicarboxylate (1448863-45-3) + phenylhydrazine (100-63-0) → 6-tert-butyl 4a-methyl 1,3-diphenyl-1,4,4a,5,6,7-hexahydropyrido[4,3-c]pyridazine-4a,6-dicarboxylate (1448863-46-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 3h; regioselective reaction;

DOI:10.1002/ejoc.201201158

Reference yield:

α-bromoacetophenone (70-11-1) + methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate (161491-24-3) → 6-tert-butyl 4a-methyl 1,3-diphenyl-1,4,4a,5,6,7-hexahydropyrido[4,3-c]pyridazine-4a,6-dicarboxylate (1448863-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 19 h / 40 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 23 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetone;

DOI:10.1002/ejoc.201201158

upstream raw materials:

1-tert-butyl 3-methyl 4-oxo-3-(2-oxo-2-phenylethyl)piperidine-1,3-dicarboxylate

phenylhydrazine

α-bromoacetophenone

methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate