(1'S,3R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester

Base Information

• Chemical Name: (1'S,3R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester
• CAS No.: 126832-14-2
• Molecular Formula: C₃₂H₃₁NO₆
• Molecular Weight: 525.601
• Mol file: 126832-14-2.mol

Synonyms:

Chemical Property of (1'S,3R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'S,3R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester

There total 12 articles about (1'S,3R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-glycine-N'-methoxy-N'-methylamide (121505-94-0) → (1'R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester (126832-13-1,126832-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / LiAlH₄ / tetrahydrofuran / 0.67 h / 0 °C

2: 1.) LDA / 1.) THF, hexane, 0 deg C, 30 min, 2.) -80 deg C to -84 deg C, 2 h

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1055/s-1989-27410

Reference yield:

N-benzyloxycarbonyl-glycine-N'-methoxy-N'-methylamide (121505-94-0) → (1'R,3S)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester (126832-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / LiAlH₄ / tetrahydrofuran / 0.67 h / 0 °C

2: 1.) LDA / 1.) THF, hexane, O deg C, 30 min, 2.) -80 deg C to -84 deg C, 2 h

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1055/s-1989-27410

Reference yield:

N-benzyloxycarbonyl-glycine-N'-methoxy-N'-methylamide (121505-94-0) → (1'S,3S)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester (126832-13-1,126832-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / LiAlH₄ / tetrahydrofuran / 0.67 h / 0 °C

2: 1.) LDA / 1.) THF, hexane, O deg C, 30 min, 2.) -80 deg C to -84 deg C, 2 h

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1055/s-1989-27410

upstream raw materials:

N-benzyloxycarbonylglycinal

(R)-2-acetoxy-1,1,2-triphenylethanol

N-benzyloxycarbonyl-glycine-N'-methoxy-N'-methylamide

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

(R)-1,1,2-triphenylethane-1,2-diol

(R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid

(S)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid

(S)-1,1,2-triphenyl-1,2-ethanediol