C₂₈H₃₄ClN₅O₂

Base Information

• Chemical Name: C₂₈H₃₄ClN₅O₂
• CAS No.: 1374567-34-6
• Molecular Formula: C₂₈H₃₄ClN₅O₂
• Molecular Weight: 508.063
• Mol file: 1374567-34-6.mol

Synonyms:

Chemical Property of C₂₈H₃₄ClN₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₄ClN₅O₂

There total 3 articles about C₂₈H₃₄ClN₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-2-(4-pyrrolidin-1-yl-piperidin-1-yl)-quinazolin-6-ylamine (710328-51-1) + Clofibric acid (882-09-7) → C28H34ClN5O2 (1374567-34-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/j.bmcl.2012.03.050

Reference yield:

4-methyl-6-nitro-2-(4-pyrrolidin-1-yl-piperidin-1-yl)-quinazoline (710328-50-0) → C28H34ClN5O2 (1374567-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.03.050

Reference yield:

4-pyrrolidinylpiperidine-1-carboxylic acid tert-butyl ester (902837-26-7) → C28H34ClN5O2 (1374567-34-6)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: triethylamine / methanol / 2 h / Reflux

3: palladium 10% on activated carbon; hydrogen / ethanol / 2 h

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.03.050

upstream raw materials:

4-methyl-2-(4-pyrrolidin-1-yl-piperidin-1-yl)-quinazolin-6-ylamine

Clofibric acid

4-methyl-6-nitro-2-(4-pyrrolidin-1-yl-piperidin-1-yl)-quinazoline

4-pyrrolidinylpiperidine-1-carboxylic acid tert-butyl ester