Clofibric acid

Base Information

Chemical Name:Clofibric acid
CAS No.:882-09-7
Molecular Formula:C10H11ClO3
Molecular Weight:214.649
Hs Code.:DERIVATION
European Community (EC) Number:212-925-9
NSC Number:756697,1149
UNII:53PF01Q249
DSSTox Substance ID:DTXSID1040661
Nikkaji Number:J7.154D
Wikipedia:Clofibric_acid
Wikidata:Q3080279
NCI Thesaurus Code:C81531
Metabolomics Workbench ID:52107
ChEMBL ID:CHEMBL683
Mol file:882-09-7.mol

Synonyms:2-(4-Chlorophenoxy)-2-methylpropionic Acid;Clofibric Acid;Clofibrinic Acid;NSC 1149;NSC-1149;NSC1149;p-Chlorophenoxyisobutyrate;p-Chlorophenoxyisobutyric Acid

Suppliers and Price of Clofibric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AHH
Clofibric acid 99%
25g
$ 328.00

AK Scientific
Clofibric acid
25mg
$ 39.00

Alfa Aesar
2-(4-Chlorophenoxy)isobutyric acid 98%
5g
$ 15.00

Ambeed
2-(4-Chlorophenoxy)-2-methylpropanoicacid 98+%
5g
$ 5.00

Ambeed
2-(4-Chlorophenoxy)-2-methylpropanoicacid 98+%
25g
$ 14.00

Ambeed
2-(4-Chlorophenoxy)-2-methylpropanoicacid 98+%
100g
$ 40.00

American Custom Chemicals Corporation
CLOFIBRIC ACID 95.00%
100MG
$ 704.55

American Custom Chemicals Corporation
CLOFIBRIC ACID 95.00%
1G
$ 1593.90

Biosynth Carbosynth
Clofibric acid
2 Kg
$ 560.00

Biosynth Carbosynth
Clofibric acid
100 g
$ 40.00

Total 112 raw suppliers

Chemical Property of Clofibric acid

Chemical Property:

Appearance/Colour:pale yellow solid
Melting Point:120-122 °C(lit.)
Refractive Index:1.5220 (estimate)
Boiling Point:324.1 °C at 760 mmHg
PKA:3.18±0.10(Predicted)
Flash Point:149.8 °C
PSA：46.53000
Density:1.265 g/cm³
LogP:2.58200
Storage Temp.:Store at RT
Solubility.:Chloroform, Methanol
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:214.0396719
Heavy Atom Count:14
Complexity:207

Purity/Quality:

99% ^*data from raw suppliers

Clofibric acid 99% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xn,Xi
Statements: 22-20/21/22
Safety Statements: 36-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C(=O)O)OC1=CC=C(C=C1)Cl
Description Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 μM in a transactivation assay) and the active metabolite of clofibrate . It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 μg/L. Clofibric acid has been found in wastewater effluent.
Uses herbicide, antihyperlipoproteinemic, antineoplastic A hypolipidemic compound

Technology Process of Clofibric acid

There total 19 articles about Clofibric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

: 31637-97-5
ETOFIBRATE

: 59-67-6
nicotinic acid

: 882-09-7
Clofibric acid

: 107-21-1
ethylene glycol

Guidance literature:: With hydrogenchloride; [RuCl₂(CO)2(Ph₂P-3-C₆H₄COOH)2]; In methanol; water; at 75 ℃; for 0.333333h;
DOI:10.1016/j.saa.2007.11.001