882-09-7 Usage
Description
2-(4-Chlorophenoxy)-2-methylpropionic acid, also known as clofibric acid, is a monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate and exhibits the properties of a pale yellow solid.
Uses
Used in Pharmaceutical Industry:
2-(4-Chlorophenoxy)-2-methylpropionic acid is used as a hypolipidemic compound for reducing serum cholesterol, phospholipid, and triglyceride levels in rats. It functions as a peroxisome proliferator-activated receptor α (PPARα) agonist, which aids in the management of lipid profiles.
Used in Agriculture:
In the agricultural sector, 2-(4-Chlorophenoxy)-2-methylpropionic acid serves as a herbicide, helping to control unwanted plant growth and protect crops.
Used in Antineoplastic Applications:
2-(4-Chlorophenoxy)-2-methylpropionic acid is utilized as an antineoplastic agent, indicating its potential role in combating cancer cells and contributing to oncological treatments.
Used in Environmental Research:
The presence of 2-(4-Chlorophenoxy)-2-methylpropionic acid in wastewater effluent highlights its relevance in environmental studies, where it can be monitored and managed to ensure ecological safety and health.
Biological Activity
PPAR agonist. Antihyperlipoproteinemic.
Check Digit Verification of cas no
The CAS Registry Mumber 882-09-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,8 and 2 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 882-09:
(5*8)+(4*8)+(3*2)+(2*0)+(1*9)=87
87 % 10 = 7
So 882-09-7 is a valid CAS Registry Number.
882-09-7Relevant articles and documents
Simultaneous GLC determination of clofibrate and clofibric acid in human plasma
Wolf,Zimmerman
, p. 92 - 93 (1980)
A simultaneous assay for the detection of clofibrate and its metabolite, clofibric acid [2-(p-chlorophenoxy)-2-methylpropionic acid], is described. This GLC method is rapid and does not require a derivatization step. It is sensitive to 1-μg/ml levels of either compound in biological samples and can be used to characterize the in vivo conversion of clofibrate ester to the free acid.
The formation of benzoxacin-3-ones: Via intramolecular Nicholas reactions and synthesis of 8-membered heliannuols
Green, James R.,St. Onge, Brent
supporting information, p. 7152 - 7155 (2021/08/30)
The γ-carbonyl cations generated from propargyl ether-Co2(CO)6 complexes undergo intramolecular Nicholas reactions to give dehydrobenzoxacin-3-one-Co2(CO)6 complexes in good yields. Reductive decomplexation and subsequent manipulation allows the synthesis of (±)-heliannuol K methyl ether and the formal syntheses of (±)-heliannuol K, (±)-heliannuol A, and (-)-heliannuol L.
Diester compounds of PPAR protein activator
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Paragraph 0056-0064, (2020/12/15)
The invention relates to diester compounds of a PPAR protein activator. The compounds are compounds shown in the formula (I) and pharmaceutically acceptable salts, prodrugs and solvates thereof, and apharmaceutical composition comprising the compounds and a synthesis method thereof. Furthermore, the invention relates to pharmaceutical composition comprising the compounds, and the pharmaceutical composition can be used for the prevention or treatment on diseases associated with PPPAR proteins.