4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide

Base Information

Chemical Name:4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide
CAS No.:181696-13-9
Molecular Formula:C₁₆H₁₂F₂N₂O₃S
Molecular Weight:350.346
Hs Code.:

Synonyms:

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Chemical Property of 4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide

Chemical Property:

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Technology Process of 4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide

There total 7 articles about 4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₀ClF₂NO₃S

: 181696-13-9
4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide

Guidance literature:: With ammonia; In dichloromethane; water; ethyl acetate; at 20 ℃; for 16h;

Reference yield:

: 100-39-0
benzyl bromide

: 181696-13-9
4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trimethylsilyl cyanide; zinc(II) iodide / dichloromethane / 16 h / 0 °C

1.2: 0.5 h / -78 - -60 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 2 h / 75 °C / Heating / reflux

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - -50 °C

3.2: 1 h / -20 °C

3.3: 16 h

4.1: toluene-4-sulfonic acid / methanol / 16 h / Heating / reflux

5.1: chlorosulfonic acid / dichloromethane / 6 h / -78 °C

6.1: ammonia / dichloromethane; water; ethyl acetate / 16 h / 20 °C

With chlorosulfonic acid; trimethylsilyl cyanide; hydroxylamine hydrochloride; ammonia; sodium acetate; toluene-4-sulfonic acid; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; ethylbenzene; water; ethyl acetate;

Reference yield:

: 181697-21-2
1-(3,5-difluorophenyl)-2-phenyl-ethan-1-one oxime

: 181696-13-9
4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - -50 °C

1.2: 1 h / -20 °C

1.3: 16 h

2.1: toluene-4-sulfonic acid / methanol / 16 h / Heating / reflux

3.1: chlorosulfonic acid / dichloromethane / 6 h / -78 °C

4.1: ammonia / dichloromethane; water; ethyl acetate / 16 h / 20 °C

With chlorosulfonic acid; ammonia; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; dichloromethane; ethylbenzene; water; ethyl acetate;