3-(3,5-difluorophenyl)-4-phenyl-5-methyl isoxazole

Base Information

Chemical Name:3-(3,5-difluorophenyl)-4-phenyl-5-methyl isoxazole
CAS No.:181697-22-3
Molecular Formula:C₁₆H₁₁F₂NO
Molecular Weight:271.266
Hs Code.:

Synonyms:

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Chemical Property of 3-(3,5-difluorophenyl)-4-phenyl-5-methyl isoxazole

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Technology Process of 3-(3,5-difluorophenyl)-4-phenyl-5-methyl isoxazole

There total 5 articles about 3-(3,5-difluorophenyl)-4-phenyl-5-methyl isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: C₁₆H₁₃F₂NO₂

: 181697-22-3
3-(3,5-difluorophenyl)-4-phenyl-5-methyl isoxazole

Guidance literature:: With toluene-4-sulfonic acid; In methanol; for 16h; Heating / reflux;

Reference yield:

: 100-39-0
benzyl bromide

: 181697-22-3
3-(3,5-difluorophenyl)-4-phenyl-5-methyl isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylsilyl cyanide; zinc(II) iodide / dichloromethane / 16 h / 0 °C

1.2: 0.5 h / -78 - -60 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 2 h / 75 °C / Heating / reflux

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - -50 °C

3.2: 1 h / -20 °C

3.3: 16 h

4.1: toluene-4-sulfonic acid / methanol / 16 h / Heating / reflux

With trimethylsilyl cyanide; hydroxylamine hydrochloride; sodium acetate; toluene-4-sulfonic acid; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; ethylbenzene; water;

Reference yield:

: 181697-21-2
1-(3,5-difluorophenyl)-2-phenyl-ethan-1-one oxime

: 181697-22-3
3-(3,5-difluorophenyl)-4-phenyl-5-methyl isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - -50 °C

1.2: 1 h / -20 °C

1.3: 16 h

2.1: toluene-4-sulfonic acid / methanol / 16 h / Heating / reflux

With toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; ethylbenzene;