C₅₆H₆₇N₅O₁₂Si

Base Information

• Chemical Name: C₅₆H₆₇N₅O₁₂Si
• CAS No.: 380615-26-9
• Molecular Formula: C₅₆H₆₇N₅O₁₂Si
• Molecular Weight: 1030.26
• Mol file: 380615-26-9.mol

Synonyms:

Chemical Property of C₅₆H₆₇N₅O₁₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₆H₆₇N₅O₁₂Si

There total 10 articles about C₅₆H₆₇N₅O₁₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid (195519-90-5) + 1-[5-(benzyloxyamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (291753-12-3) → C56H67N5O12Si (380615-26-9)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In acetonitrile; at 20 ℃;

DOI:10.1016/S0040-4039(00)00661-4

Reference yield:

[(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetaldehyde (128119-39-1) → C56H67N5O12Si (380615-26-9)

Guidance literature:

Multi-step reaction with 6 steps

1: NaClO₂; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

2: 87 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N,N-dimethylaminopyridine / H₂O

3: Bu₄NF; pyridine / tetrahydrofuran; H₂O

4: TEA / CH₂Cl₂

5: aq. NaOH / tetrahydrofuran

6: O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); N-hydroxybenzotriazole / acetonitrile / 20 °C

With pyridine; dmap; sodium hydroxide; sodium chlorite; 2-methyl-but-2-ene; O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); TEA; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;

DOI:10.1081/NCN-100002513

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) → C56H67N5O12Si (380615-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 12 h / 100 °C

2: sodium cyanoborohydride / methanol; acetic acid / 6 h / 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); N-hydroxybenzotriazole / acetonitrile / 20 °C

With pyridine; O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); sodium cyanoborohydride; benzotriazol-1-ol; In methanol; acetic acid; acetonitrile;

DOI:10.1081/NCN-100002513

upstream raw materials:

[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

1-[5-(benzyloxyamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

[(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetaldehyde

O-benzylhydoxylamine hydrochloride

Downstream raw materials:

N-benzyloxy-2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide