Benzene, 2,4-dimethoxy-1-(trifluoromethyl)-

Base Information

• Chemical Name: Benzene, 2,4-dimethoxy-1-(trifluoromethyl)-
• CAS No.: 106877-42-3
• Molecular Formula: C9H9F3O2
• Molecular Weight: 206.164
• Mol file: 106877-42-3.mol

Synonyms:2,4-dimethoxy-(trifluoromethyl)benzene;2,4-Dimethoxy-1-trifluoromethyl-benzene;1,3-dimethoxy-4-trifluoromethylbenzene;2,4-dimethoxy-1-(trifluoromethyl)benzene;

Chemical Property of Benzene, 2,4-dimethoxy-1-(trifluoromethyl)-

Chemical Property:

• PSA: 18.46000
• LogP: 2.72260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 2,4-dimethoxy-1-(trifluoromethyl)-

There total 16 articles about Benzene, 2,4-dimethoxy-1-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-iodo-2,4-dimethoxybenzene (20469-63-0) + trifluoromethylcopper(I) (77152-08-0) → 1,3-dimethoxy-4-(trifluoromethyl)benzene (106877-42-3)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In N,N-dimethyl-formamide; at 23 ℃; for 72h; Temperature; Time; Inert atmosphere;

DOI:10.1021/jo401423h

Reference yield: 67.0%

Langlois reagent (2926-29-6) + 1,3-Dimethoxybenzene (151-10-0) → 1,3-dimethoxy-4-(trifluoromethyl)benzene (106877-42-3) + 1,3-di-methoxy-2-(trifluoromethyl)benzene (106877-43-4)

Guidance literature:

With acetone; at 20 ℃; for 40h; UV-irradiation; Inert atmosphere;

DOI:10.1021/jacs.6b02782

Reference yield: 65.0%

2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate (1214756-50-9) + 2,4-dimethoxyphenylboronic acid (133730-34-4) → 1,3-dimethoxy-4-(trifluoromethyl)benzene (106877-42-3)

Guidance literature:

With 2,4,6-trimethyl-pyridine; copper diacetate; In ethyl acetate; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00164

upstream raw materials:

Langlois reagent

1,3-Dimethoxybenzene

potassium triflinate

(trifluoromethyl)trimethylsilane