(S)-Phenyl-phosphonic acid (2R,3R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-3-methylamino-tetrahydro-pyran-2-yl ester ethyl ester

Base Information

• Chemical Name: (S)-Phenyl-phosphonic acid (2R,3R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-3-methylamino-tetrahydro-pyran-2-yl ester ethyl ester
• CAS No.: 88065-93-4
• Molecular Formula: C₁₈H₃₀NO₇P
• Molecular Weight: 403.412
• Mol file: 88065-93-4.mol

Synonyms:

Chemical Property of (S)-Phenyl-phosphonic acid (2R,3R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-3-methylamino-tetrahydro-pyran-2-yl ester ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Phenyl-phosphonic acid (2R,3R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-3-methylamino-tetrahydro-pyran-2-yl ester ethyl ester

There total 4 articles about (S)-Phenyl-phosphonic acid (2R,3R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-3-methylamino-tetrahydro-pyran-2-yl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

sodium ethanolate (141-52-6) + 1-O,2-N-<(S)-phenylphosphoryl>-2-deoxy-2-methylamino-3,4,6-tri-O-methyl-α-D-glucopyranoside (88065-86-5,88155-07-1,88155-08-2,88155-09-3) → (S)-Phenyl-phosphonic acid (2R,3R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-3-methylamino-tetrahydro-pyran-2-yl ester ethyl ester (88065-93-4) + C18H30NO7P (88066-01-7,88066-02-8)

Guidance literature:

In ethanol; for 1h;

Reference yield:

P,P-dichlorophenylphosphine oxide (824-72-6) → (S)-Phenyl-phosphonic acid (2R,3R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-3-methylamino-tetrahydro-pyran-2-yl ester ethyl ester (88065-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 22 percent / triethylamine / benzene / 2 h

2: hydrogen chloride

With hydrogenchloride; triethylamine; In benzene;

Reference yield:

2-deoxy-2-methylamino-3,4,6-tri-O-methyl-α-D-glucopyranose hydrochloride (33423-07-3) → (S)-Phenyl-phosphonic acid (2R,3R,4R,5S,6R)-4,5-dimethoxy-6-methoxymethyl-3-methylamino-tetrahydro-pyran-2-yl ester ethyl ester (88065-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 22 percent / triethylamine / benzene / 2 h

2: hydrogen chloride

With hydrogenchloride; triethylamine; In benzene;

upstream raw materials:

ethanol

1-O,2-N-<(S)-phenylphosphoryl>-2-deoxy-2-methylamino-3,4,6-tri-O-methyl-α-D-glucopyranoside

sodium ethanolate

P,P-dichlorophenylphosphine oxide

Downstream raw materials:

ethyl hydrogen phenylphosphonate

diethyl phenylphosphonate