di-(-)-menthyl diethylmalonate

Base Information

• Chemical Name: di-(-)-menthyl diethylmalonate
• CAS No.: 528846-20-0
• Molecular Formula: C₂₇H₄₈O₄
• Molecular Weight: 436.676
• Mol file: 528846-20-0.mol

Synonyms:

Chemical Property of di-(-)-menthyl diethylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-(-)-menthyl diethylmalonate

There total 4 articles about di-(-)-menthyl diethylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

di-l-menthyl malonate (73636-64-3) + ethyl iodide (75-03-6) → di-(-)-menthyl diethylmalonate (528846-20-0)

Guidance literature:

di-l-menthyl malonate; With sodium ethanolate; In tetrahydrofuran; for 1h;

ethyl iodide; In tetrahydrofuran; for 3h;

DOI:10.1080/10242430215697

Reference yield:

(-)-menthol (2216-51-5) → di-(-)-menthyl diethylmalonate (528846-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 66 percent / triethylamine / CCl₃F / 1 h

2.1: sodium ethoxide / tetrahydrofuran / 1 h

2.2: 70 percent / tetrahydrofuran / 3 h

With sodium ethanolate; triethylamine; In tetrahydrofuran; trichlorofluoromethane;

DOI:10.1080/10242430215697

Reference yield:

diethylmalonic acid dimethyl ester (27132-23-6) + (-)-menthol (2216-51-5) → di-(-)-menthyl diethylmalonate (528846-20-0)

Guidance literature:

With sodium menthoxide; at 120 - 130 ℃;

upstream raw materials:

diethylmalonic acid dimethyl ester

(-)-menthol

diethylmalonyl chloride

di-l-menthyl malonate