(R)-4-bromo-1-cyanobutyl acetate

Base Information

Chemical Name:(R)-4-bromo-1-cyanobutyl acetate
CAS No.:1393708-93-4
Molecular Formula:C₇H₁₀BrNO₂
Molecular Weight:220.066
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-bromo-1-cyanobutyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (R)-4-bromo-1-cyanobutyl acetate

There total 2 articles about (R)-4-bromo-1-cyanobutyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 38694-47-2
4-bromobutyraldehyde

: 631-57-2
Acetyl cyanide

: 539820-24-1
(S)-tetrahydrofuran-2-carbonitrile

: 1393708-93-4
(R)-4-bromo-1-cyanobutyl acetate

: 164472-78-0
(R)-(tetrahydrofuran-2-yl)carbonitrile

: (S)-4-bromo-1-cyanobutyl alcohol

Guidance literature:: With Candida antarctica lipase B; di-μ-oxo-di((S,S)-N,N'-bis((salicylaldehydo)ethylenediamine))dititanium(IV); water; In toluene; at 20 ℃; for 15h; pH=6; optical yield given as %ee; enantioselective reaction; aq. buffer; Enzymatic reaction;
DOI:10.1016/j.tet.2012.05.090

Reference yield: 34.0%

: 38694-47-2
4-bromobutyraldehyde

: 631-57-2
Acetyl cyanide

: 14631-43-7
2-tetrahydrofuran-2-carbonitrile

: 1393708-93-4
(R)-4-bromo-1-cyanobutyl acetate

Guidance literature:: With Candida antarctica lipase B; di-μ-oxo-di((S,S)-N,N'-bis((salicylaldehydo)ethylenediamine))dititanium(IV); water; In toluene; at 40 ℃; for 15h; pH=6; optical yield given as %ee; enantioselective reaction; aq. buffer; Enzymatic reaction;
DOI:10.1016/j.tet.2012.05.090

Reference yield:

: 1393708-93-4
(R)-4-bromo-1-cyanobutyl acetate

: 164472-78-0
(R)-(tetrahydrofuran-2-yl)carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / ethanol / 44.5 h / 20 °C

2: silver perchlorate / dichloromethane / 1 h / 20 °C

With silver perchlorate; toluene-4-sulfonic acid; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2012.05.090