{9-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

Base Information

• Chemical Name: {9-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine
• CAS No.: 99798-05-7
• Molecular Formula: C₄₆H₅₅N₅O₅Si
• Molecular Weight: 786.059
• Mol file: 99798-05-7.mol

Synonyms:

Chemical Property of {9-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {9-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

There total 1 articles about {9-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + 1,1'-Thiocarbonyldiimidazole (6160-65-2) + 5'-O-(4,4'-dimethoxytriphenylmethyl)-N-(1-methyl-2-phenylethyl)adenosine → {9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine (99798-06-8) + {9-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine (99798-05-7)

Guidance literature:

With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; silver nitrate; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jm00153a008

Reference yield:

{9-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine (99798-05-7) → (2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-[6-((R)-1-methyl-2-phenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3-ol

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.25h;

DOI:10.1021/jm00153a008

Reference yield:

{9-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine (99798-05-7) → 3'-deoxy-N6(R)-(phenylisopropyl)adenosine

Guidance literature:

Multi-step reaction with 2 steps

1: 1 M Bu₄NF / tetrahydrofuran / 0.25 h

2: 80percent AcOH / 0.75 h

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;

DOI:10.1021/jm00153a008

upstream raw materials:

tert-butyldimethylsilyl chloride

1,1'-Thiocarbonyldiimidazole