{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

Base Information

Chemical Name:{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine
CAS No.:99798-06-8
Molecular Formula:C₄₆H₅₅N₅O₅Si
Molecular Weight:786.059
Hs Code.:

{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

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Chemical Property of {9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

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Technology Process of {9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

There total 1 articles about {9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 5'-O-(4,4'-dimethoxytriphenylmethyl)-N-(1-methyl-2-phenylethyl)adenosine

: 99798-06-8
{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

: 99798-05-7
{9-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

Guidance literature:: With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; silver nitrate; Yield given. Multistep reaction. Yields of byproduct given;
DOI:10.1021/jm00153a008

Reference yield:

: 99798-06-8
{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

: (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-((R)-1-methyl-2-phenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.25h;
DOI:10.1021/jm00153a008

Reference yield:

: 99798-06-8
{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-((R)-1-methyl-2-phenyl-ethyl)-amine

: 2'-deoxy-N⁶(R)-(phenylisopropyl)adenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 1 M Bu₄NF / tetrahydrofuran / 0.25 h

2: 80percent AcOH / 0.75 h

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm00153a008