1-(5-Bromo-1H-indol-3-yl)-2,2,2-trichloroethanone

Base Information

• Chemical Name: 1-(5-Bromo-1H-indol-3-yl)-2,2,2-trichloroethanone
• CAS No.: 1336879-56-1
• Molecular Formula: C₁₀H₅BrCl₃NO
• Molecular Weight: 341.419
• Mol file: 1336879-56-1.mol

Synonyms:

Chemical Property of 1-(5-Bromo-1H-indol-3-yl)-2,2,2-trichloroethanone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-(5-Bromo-1H-indol-3-yl)-2,2,2-trichloroethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-Bromo-1H-indol-3-yl)-2,2,2-trichloroethanone

There total 1 articles about 1-(5-Bromo-1H-indol-3-yl)-2,2,2-trichloroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-1H-indole (10075-50-0) + trifluoroacetyl chloride (76-02-8) → 2,2,2-trichloro-1-(5-bromo-1H-indol-3-yl)ethan-1-one (1336879-56-1)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2016.03.048

Reference yield: 86.0%

methanol (67-56-1) + 2,2,2-trichloro-1-(5-bromo-1H-indol-3-yl)ethan-1-one (1336879-56-1) → 5-bromo-1H-indole-3-carboxylic acid methyl ester (773873-77-1)

Guidance literature:

With potassium hydroxide; In water; at 85 ℃; for 3h;

DOI:10.1016/j.tet.2016.03.048

Reference yield:

2,2,2-trichloro-1-(5-bromo-1H-indol-3-yl)ethan-1-one (1336879-56-1) → C22H26BrNO3Si

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 50 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 1 h / 0 °C

With sodium hydride; In N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

5-bromo-1H-indole

trifluoroacetyl chloride

Downstream raw materials:

5-bromo-1H-indole-3-carboxylic acid methyl ester

Refernces

• 1、 Choo, Hyeonseong,Hong, Victor Sukbong,Jeong, Seungik,Lee, Jinho,Won, Jongin,Yun, Yanghwan. "1,3,4-Oxadiazole-2(3H)-thione Analogs as PIM Kinase Inhibitors". . p. 994 - 1001. Retrieved 2020/10/02.