Benzoic acid, 4-methyl-, methylene ester

Base Information

• Chemical Name: Benzoic acid, 4-methyl-, methylene ester
• CAS No.: 111008-64-1
• Molecular Formula: C17H16O4
• Molecular Weight: 284.312
• Mol file: 111008-64-1.mol

Synonyms:

Chemical Property of Benzoic acid, 4-methyl-, methylene ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-methyl-, methylene ester

There total 7 articles about Benzoic acid, 4-methyl-, methylene ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dichloromethane (75-09-2) + p-Toluic acid (99-94-5) → bis(4-methylbenzoyloxy)methane (111008-64-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In neat (no solvent); at 80 ℃; for 0.75h; Microwave irradiation;

DOI:10.1016/j.cclet.2014.11.001

Reference yield: 90.0%

p-Toluic acid (99-94-5) + 1,1-dibromomethane (74-95-3) → bis(4-methylbenzoyloxy)methane (111008-64-1)

Guidance literature:

With anion exchange resin; for 5h; Heating;

Reference yield: 85.0%

potassium p-methyl benzoate (16518-25-5) + 1,1-dibromomethane (74-95-3) → bis(4-methylbenzoyloxy)methane (111008-64-1)

Guidance literature:

With poly(ethylene glycol)-600; In acetonitrile; for 10h; Ambient temperature;

DOI:10.1080/00397919708004081

upstream raw materials:

p-Toluic acid

1,1-dibromomethane

potassium p-methyl benzoate

diiodomethane

Refernces

• 1、 Bai, Lin,Ding, Shenglong,Ma, Xiaofang. "Solvent-free synthesis of symmetric methylene diestersviadirect reaction of aromatic carboxylates with 1,n-dihaloalkanes". . p. 28711 - 28715. Retrieved 2021/09/22.
• 2、 Zhang, Yang-Hui,Shi, Bing-Feng,Yu, Jin-Quan. "Palladium(II)-catalyzed ortho alkylation of benzoic acids with alkyl halides". supporting information; experimental part. p. 6097 - 6100. Retrieved 2009/12/09.