3,4-methylenedioxybenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone

Base Information

• Chemical Name: 3,4-methylenedioxybenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone
• CAS No.: 1285705-99-8
• Molecular Formula: C₁₇H₁₇N₃O₅S
• Molecular Weight: 375.405
• Mol file: 1285705-99-8.mol

Synonyms:

Chemical Property of 3,4-methylenedioxybenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-methylenedioxybenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone

There total 3 articles about 3,4-methylenedioxybenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.9%

piperonal (120-57-0,30024-74-9) + p-methylphenylsulfonylaminoacetic acid hydrazide (3619-20-3) → 3,4-methylenedioxybenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone (1285705-99-8)

Guidance literature:

With acetic acid; In methanol; Reflux;

DOI:10.1111/j.1747-0285.2010.01050.x

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 3,4-methylenedioxybenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone (1285705-99-8)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 20 h / 20 °C / Cooling with ice

2: hydrazine hydrate / ethanol / 6 h / Reflux

3: acetic acid / methanol / Reflux

With dmap; hydrazine hydrate; acetic acid; triethylamine; In methanol; ethanol; dichloromethane;

DOI:10.1111/j.1747-0285.2010.01050.x

Reference yield:

methyl tosylglycinate (2645-02-5) → 3,4-methylenedioxybenzaldehyde N-(4-toluenesulfonyl)-glycinyl hydrazone (1285705-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 6 h / Reflux

2: acetic acid / methanol / Reflux

With hydrazine hydrate; acetic acid; In methanol; ethanol;

DOI:10.1111/j.1747-0285.2010.01050.x

upstream raw materials:

piperonal

p-methylphenylsulfonylaminoacetic acid hydrazide

methyl tosylglycinate

p-toluenesulfonyl chloride