(2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid

Base Information

• Chemical Name: (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid
• CAS No.: 119460-19-4
• Molecular Formula: C₂₄H₃₅N₅O₈S
• Molecular Weight: 553.637
• Mol file: 119460-19-4.mol

Synonyms:

Chemical Property of (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid

There total 2 articles about (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5S)-5-benzyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid (37700-64-4) → (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid (119460-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 5 h

2: dimethylformamide / 15 h / 20 °C

With hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

L-phenylalanylglycylglycine (23576-42-3) + (S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionic acid 4-nitro-phenyl ester (58651-76-6) → (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid (119460-19-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 15h; Yield given;

Reference yield: 72.0%

N-hydroxy-5-norbornene-2,3-dicarboximide (21715-90-2) + (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid (119460-19-4) → (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester (119439-67-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.)-10 deg C, 1 h 2.)4 deg C, 2 h 3.)20 deg C, 10 h;

upstream raw materials:

L-phenylalanylglycylglycine

(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionic acid 4-nitro-phenyl ester

(5S)-5-benzyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid

Downstream raw materials:

(2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl ester

(2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-amino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid

C₅₈H₉₇N₁₇O₁₆S

C₆₃H₁₀₉N₁₇O₁₇S