37700-64-4

Usage

Uses

Used in Pharmaceutical Drug Development:
Z-PHE-GLY-GLY-OH is used as a model compound for the development of new pharmaceutical drugs, owing to its ability to mimic the structure and function of larger proteins and peptides. This allows researchers to study the interactions of the compound with biological targets and evaluate its potential therapeutic effects.
Used in Biochemical Research:
In the field of biochemistry, Z-PHE-GLY-GLY-OH is used as a research tool to understand the interactions and behaviors of amino acids and their derivatives. This knowledge aids in the elucidation of fundamental biochemical processes and the identification of potential therapeutic targets.
Used in Cellular and Molecular Process Studies:
Z-PHE-GLY-GLY-OH is employed in the study of cellular and molecular processes to investigate the compound's effects on various biological pathways. This research contributes to a deeper understanding of the mechanisms underlying cellular functions and the development of targeted therapeutic interventions.
Used in the Design of Therapeutic Agents:
Z-PHE-GLY-GLY-OH is utilized in the design of new therapeutic agents targeting specific biological pathways. By mimicking the structure and function of larger proteins and peptides, the compound can be engineered to modulate the activity of key biological targets, offering potential therapeutic benefits in various diseases and conditions.

InChI:InChI=1/C21H23N3O6/c25-18(22-13-19(26)27)12-23-20(28)17(11-15-7-3-1-4-8-15)24-21(29)30-14-16-9-5-2-6-10-16/h1-10,17H,11-14H2,(H,22,25)(H,23,28)(H,24,29)(H,26,27)

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 1161-13-3 N-Cbz-L-Phe 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 6372-14-1 N-((benzyloxy)carbonyl)-L-phenylalaninol 
• 13122-99-1 (S)-2-(2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)acetic acid 
• 4864-80-6 benzyl (S)-(1-((2-hydroxyethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 501-53-1 benzyl chloroformate 
• 116506-70-8 N-benzyloxycarbonyl-L-phenylalanylglycylaminoethanol 
• 556-50-3 glycylglycine 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 
• 769922-77-2 (S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 

Downstream Products

• 75719-85-6 N-benzyloxycarbonyl-L-phenylalanylglycylglycine pentachlorophenyl ester 
• 23576-42-3 L-phenylalanylglycylglycine 
• 119645-66-8 Cbz-L-Phe-Gly-Gly-L-Trp-OH 
• 1342794-12-0 Cbz-L-Phe-Gly-Gly-Gly-L-Leu-OH 
• 1342794-31-3 Cbz-L-Phe-L-Gly-L-Gly-L-Ser-OH 
• 1342794-19-7 Cbz-L-Phe-Gly-Gly-L-Val-OH 
• 1342794-06-2 Cbz-L-Phe-Gly-Gly-Bt 
• 117951-67-4 (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-amino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid 
• 119082-79-0 [2-((S)-2-{(S)-3-(Acetylamino-methylsulfanyl)-2-[(S)-3-tert-butoxy-2-((S)-3-tert-butoxy-2-tert-butoxycarbonylamino-propionylamino)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-acetylamino]-acetic acid 
• 119439-67-7 (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl ester 
• 119460-19-4 (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid 
• 117951-71-0 C₆₃H₁₀₉N₁₇O₁₇S 
• 119439-58-6 C₅₈H₉₇N₁₇O₁₆S 
• 75720-05-7 1-O-(L-phenylalanylglycylglycyl)-β-D-glucopyranose 

Relevant academic research and scientific papers

Highly diastereoselective peptide chain extensions of unprotected amino acids with N-(Z-α-aminoacyl)benzotriazoles

Coupling an unprotected amino acid or dipeptide in partially aqueous solution with a readily available N-(Z-α-amino-acyl)benzotriazole or N-(Z-α-aminopetidoyl)benzotriazole affords N-terminal-protected di-, tri-, and tetrapeptides in yields of 85-98% (average 95% for 2a-i, 93% for 4a-f and 4a′, 86% for 5a-b) with minimal epimerization.

ATRIOPEPTINS. II. SYNTHESIS OF N-TERMINAL FRAGMENTS

Peptides, corresponding to the N-terminal sequence in atriopeptins, were synthesized by classical methods of peptide chemistry in solutions.The obtained peptides were characterized by various physicochemical methods.The scheme and methods of the synthesis are discussed.

Amino alcohols as C-Terminal Protecting Groups in Peptide Synthesis

The synthesis of peptides using amino alcohols as C-terminal protecting groups is described.C-Terminal protection of amino acid could be accomplished by reduction of the terminal carboxyl group to a hydroxymethyl group, and regeneration of the carboxyl group could be achieved by Jones' oxidation.This method was applied to the formation of di- and tripeptides.