37700-64-4

Basic information

• Product Name: Z-PHE-GLY-GLY-OH
• Synonyms: Z-PHE-GLY-GLY-OH
• CAS NO: 37700-64-4
• Molecular Formula: C₂₁H₂₃N₃O₆
• Molecular Weight: 413.42
• Mol File: 37700-64-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 795.1°Cat760mmHg
• Flash Point: 434.7°C
• Appearance: /
• Density: 1.301g/cm³
• Vapor Pressure: 1.16E-26mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-PHE-GLY-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-PHE-GLY-GLY-OH(37700-64-4)
• EPA Substance Registry System: Z-PHE-GLY-GLY-OH(37700-64-4)

Safety Data

• Hazardous Substances Data: 37700-64-4(Hazardous Substances Data)

Usage

General Description

Z-PHE-GLY-GLY-OH is a chemical compound composed of the amino acids phenylalanine, glycine, and glycine, with an additional hydroxyl group. Z-PHE-GLY-GLY-OH is commonly used in the field of biochemistry and pharmacology for its ability to mimic the structure and function of larger proteins and peptides. It is often used in the development of new pharmaceutical drugs and in the study of cellular and molecular processes. Z-PHE-GLY-GLY-OH may also be used in research to understand the interactions and behaviors of amino acids and their derivatives, as well as in the design of new therapeutic agents targeting specific biological pathways.

InChI:InChI=1/C21H23N3O6/c25-18(22-13-19(26)27)12-23-20(28)17(11-15-7-3-1-4-8-15)24-21(29)30-14-16-9-5-2-6-10-16/h1-10,17H,11-14H2,(H,22,25)(H,23,28)(H,24,29)(H,26,27)

Upstream product

• 116506-70-8 N-benzyloxycarbonyl-L-phenylalanylglycylaminoethanol 
• 501-53-1 benzyl chloroformate 
• 4864-80-6 benzyl (S)-(1-((2-hydroxyethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 13122-99-1 (S)-2-(2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)acetic acid 
• 6372-14-1 N-((benzyloxy)carbonyl)-L-phenylalaninol 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 1161-13-3 N-Cbz-L-Phe 
• 3182-95-4 L-Phenylalaninol 
• 556-50-3 glycylglycine 
• 769922-77-2 (S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 

Downstream Products

• 75719-85-6 N-benzyloxycarbonyl-L-phenylalanylglycylglycine pentachlorophenyl ester 
• 119645-66-8 Cbz-L-Phe-Gly-Gly-L-Trp-OH 
• 1342794-12-0 Cbz-L-Phe-Gly-Gly-Gly-L-Leu-OH 
• 1342794-31-3 Cbz-L-Phe-L-Gly-L-Gly-L-Ser-OH 
• 1342794-19-7 Cbz-L-Phe-Gly-Gly-L-Val-OH 
• 1342794-06-2 Cbz-L-Phe-Gly-Gly-Bt 
• 117951-67-4 (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-amino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid 
• 119082-79-0 [2-((S)-2-{(S)-3-(Acetylamino-methylsulfanyl)-2-[(S)-3-tert-butoxy-2-((S)-3-tert-butoxy-2-tert-butoxycarbonylamino-propionylamino)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-acetylamino]-acetic acid 
• 119439-67-7 (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl ester 
• 119460-19-4 (2-{(S)-2-[(S)-3-(Acetylamino-methylsulfanyl)-2-tert-butoxycarbonylamino-propionylamino]-3-phenyl-propionylamino}-acetylamino)-acetic acid 
• 117951-71-0 C₆₃H₁₀₉N₁₇O₁₇S 
• 119439-58-6 C₅₈H₉₇N₁₇O₁₆S 
• 75720-05-7 1-O-(L-phenylalanylglycylglycyl)-β-D-glucopyranose 
• 75719-89-0 2,3,4,6-tetra-O-benzyl-1-O-(N-benzyloxycarbonyl-L-phenylalanylglycylglycyl)-α-D-glucopyranose 

Relevant articles and documents

Highly diastereoselective peptide chain extensions of unprotected amino acids with N-(Z-α-aminoacyl)benzotriazoles

Coupling an unprotected amino acid or dipeptide in partially aqueous solution with a readily available N-(Z-α-amino-acyl)benzotriazole or N-(Z-α-aminopetidoyl)benzotriazole affords N-terminal-protected di-, tri-, and tetrapeptides in yields of 85-98% (average 95% for 2a-i, 93% for 4a-f and 4a′, 86% for 5a-b) with minimal epimerization.

Amino alcohols as C-Terminal Protecting Groups in Peptide Synthesis

The synthesis of peptides using amino alcohols as C-terminal protecting groups is described.C-Terminal protection of amino acid could be accomplished by reduction of the terminal carboxyl group to a hydroxymethyl group, and regeneration of the carboxyl group could be achieved by Jones' oxidation.This method was applied to the formation of di- and tripeptides.