23576-42-3Relevant articles and documents
N -boc deprotection and isolation method for water-soluble zwitterionic compounds
Liu, Zhijian,Yasuda, Nobuyoshi,Simeone, Michael,Reamer, Robert A.
, p. 11792 - 11796 (2015/02/19)
A highly efficient TMSI-mediated deprotection and direct isolation method to obtain zwitterionic compounds from the corresponding N-Boc derivatives has been developed. This method has been demonstrated in the final deprotection/isolation of the β-lactamase inhibitor MK-7655 as a part of its manufacturing process. Further application of this process toward other zwitterionic compounds, such as dipeptides and tripeptides, has been successfully developed. Furthermore, a catalytic version of this transformation has been demonstrated in the presence of BSA or BSTFA.
ATRIOPEPTINS. II. SYNTHESIS OF N-TERMINAL FRAGMENTS
Ovchinnikov, Mikhail V.,Bespalova, Zhanna D.,Molokoedov, Aleksandr S.,Revenko, Inna V.,Sepetov, Nikolai F.,et al
, p. 784 - 795 (2007/10/02)
Peptides, corresponding to the N-terminal sequence in atriopeptins, were synthesized by classical methods of peptide chemistry in solutions.The obtained peptides were characterized by various physicochemical methods.The scheme and methods of the synthesis are discussed.