N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide

Base Information

• Chemical Name: N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide
• CAS No.: 226558-71-0
• Molecular Formula: C₂₁H₂₄N₆O₇
• Molecular Weight: 472.458
• Mol file: 226558-71-0.mol

Synonyms:

Chemical Property of N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide

There total 3 articles about N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phenoxyacetyl chloride (701-99-5) → N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide (226558-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine / CH₂Cl₂; acetonitrile / 0.17 h

2: 1) TMSCl / 1) pyridine, 1 h, 2) pyridine, CH₂Cl₂, 36 h

3: pyridine / 1 h

With 4-methyl-morpholine; pyridine; chloro-trimethyl-silane; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(99)00733-9

Reference yield:

phenoxyacetyl-1-O-benzotriazolide (375345-66-7) → N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide (226558-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) TMSCl / 1) pyridine, 1 h, 2) pyridine, CH₂Cl₂, 36 h

2: pyridine / 1 h

With pyridine; chloro-trimethyl-silane;

DOI:10.1016/S0040-4039(99)00733-9

Reference yield:

N2-(phenoxyacetyl)guanosine (119824-66-7) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → N-[9-(2-dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide (226558-71-0)

Guidance literature:

With pyridine; for 1h;

DOI:10.1016/S0040-4039(99)00733-9

upstream raw materials:

N²-(phenoxyacetyl)guanosine

N,N-dimethyl-formamide dimethyl acetal

Phenoxyacetyl chloride

phenoxyacetyl-1-O-benzotriazolide

Downstream raw materials:

5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N₂-phenoxyacetylguanosine

5′-O-(dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N2-phenoxyacetylguanosine