(3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)-6-methylbicyclo<4.2.0>octan-7-one

Base Information

Chemical Name:(3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)-6-methylbicyclo<4.2.0>octan-7-one
CAS No.:129065-91-4
Molecular Formula:C₃₀H₅₄O₃Si₂
Molecular Weight:518.928
Hs Code.:

(3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)-6-methylbicyclo<4.2.0>octan-7-one

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Chemical Property of (3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)-6-methylbicyclo<4.2.0>octan-7-one

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Technology Process of (3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)-6-methylbicyclo<4.2.0>octan-7-one

There total 4 articles about (3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)-6-methylbicyclo<4.2.0>octan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105803-42-7
(3'S,1S,2S,3R,6S)-2-(3'-cyclohexyl-3'-hydroxyprop-1'-ynyl)-3-hydroxybicyclo<4.2.0>octan-7-one

: 129065-91-4
(3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)-6-methylbicyclo<4.2.0>octan-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 16 h / 24 °C

2: 1.)lithium hexamethyldisilazide (LiHMDS) / 1.)THF, -78 deg C, 30 min.; or with lithium diisopropylamide (LDA)

With 1H-imidazole; lithium hexamethyldisilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jo00304a020

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 129065-91-4
(3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)-6-methylbicyclo<4.2.0>octan-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 16 h / 24 °C

2: 1.)lithium hexamethyldisilazide (LiHMDS) / 1.)THF, -78 deg C, 30 min.; or with lithium diisopropylamide (LDA)

With 1H-imidazole; lithium hexamethyldisilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jo00304a020

Reference yield:

: 129065-90-3
(3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)bicyclo<4.2.0>octan-7-one

: 74-88-4
methyl iodide

: 129065-91-4
(3'S,1R,2S,3R,6S)-2-(3'-((tert-Butyldimethylsilyl)oxy)-3'-cyclohexylprop-1'-ynyl)-3-((tert-butyldimethylsilyl)oxy)-6-methylbicyclo<4.2.0>octan-7-one

Guidance literature:: With lithium hexamethyldisilazane; Yield given. Multistep reaction; 1.)THF, -78 deg C, 30 min.; or with lithium diisopropylamide (LDA);
DOI:10.1021/jo00304a020