Technology Process of (1S,8S,9R,11S)-10-(2,4-dinitroanilino)-3,3,5,5-tetraisopropyl-2,4,6-trioxa-10-aza-3,5-disilatricyclo<6.4.0.09,11>dodecane
There total 12 articles about (1S,8S,9R,11S)-10-(2,4-dinitroanilino)-3,3,5,5-tetraisopropyl-2,4,6-trioxa-10-aza-3,5-disilatricyclo<6.4.0.09,11>dodecane which
guide to synthetic route it.
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synthetic route:
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117641-41-5
(1S,8S,9R,11S)-10-(2,4-dinitroanilino)-3,3,5,5-tetraisopropyl-2,4,6-trioxa-10-aza-3,5-disilatricyclo<6.4.0.09,11>dodecane
- Guidance literature:
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Multi-step reaction with 5 steps
1: 1.58 g / CH2Cl2; pyridine / 5 h
2: 1.29 g / sodium azide, ammonium chloride / H2O; ethanol / 4 h / Heating
3: 0.63 g / H2 / Lindlar catalyst / ethanol / 2 h / 760 Torr
4: 0.63 g / Na2CO3 / dimethylformamide / 18 h / Ambient temperature
5: 0.125 g / diethylaminosulphur trifluoride / CH2Cl2 / 0.17 h
With
sodium azide; diethylamino-sulfur trifluoride; ammonium chloride; hydrogen; sodium carbonate;
Lindlar's catalyst;
In
pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/P19880000549
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117641-41-5
(1S,8S,9R,11S)-10-(2,4-dinitroanilino)-3,3,5,5-tetraisopropyl-2,4,6-trioxa-10-aza-3,5-disilatricyclo<6.4.0.09,11>dodecane
- Guidance literature:
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Multi-step reaction with 9 steps
1: 15.8 g / (-)-diisopinan-3-ylborane / tetrahydrofuran / 1.) -60 deg C, 1 h; 2.) 5 deg C, 18 h
2: 12.0 g / t-butyl hydroperoxide, vanadium(V)acetylacetonate / 1,2-dichloro-ethane / 2.75 h / 30 °C
3: 1.) NaH; 2.) tetrabutylammonium iodide / 1.) THF, 2 h; 1.) THF, 2.5 h
4: 100 percent / H2 / 10percent Pd/C
5: 1.58 g / CH2Cl2; pyridine / 5 h
6: 1.29 g / sodium azide, ammonium chloride / H2O; ethanol / 4 h / Heating
7: 0.63 g / H2 / Lindlar catalyst / ethanol / 2 h / 760 Torr
8: 0.63 g / Na2CO3 / dimethylformamide / 18 h / Ambient temperature
9: 0.125 g / diethylaminosulphur trifluoride / CH2Cl2 / 0.17 h
With
tert.-butylhydroperoxide; sodium azide; tris(acetylacetonato)vanadium(III); diethylamino-sulfur trifluoride; (-)-diisopinan-3-ylborane; ammonium chloride; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate;
palladium on activated charcoal; Lindlar's catalyst;
In
tetrahydrofuran; pyridine; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1039/P19880000549
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117641-41-5
(1S,8S,9R,11S)-10-(2,4-dinitroanilino)-3,3,5,5-tetraisopropyl-2,4,6-trioxa-10-aza-3,5-disilatricyclo<6.4.0.09,11>dodecane
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / H2 / 10percent Pd/C
2: 1.58 g / CH2Cl2; pyridine / 5 h
3: 1.29 g / sodium azide, ammonium chloride / H2O; ethanol / 4 h / Heating
4: 0.63 g / H2 / Lindlar catalyst / ethanol / 2 h / 760 Torr
5: 0.63 g / Na2CO3 / dimethylformamide / 18 h / Ambient temperature
6: 0.125 g / diethylaminosulphur trifluoride / CH2Cl2 / 0.17 h
With
sodium azide; diethylamino-sulfur trifluoride; ammonium chloride; hydrogen; sodium carbonate;
palladium on activated charcoal; Lindlar's catalyst;
In
pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/P19880000549
