[(4-Methoxy-phenyl)-diphenyl-methyl]-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-amine

Base Information

• Chemical Name: [(4-Methoxy-phenyl)-diphenyl-methyl]-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-amine
• CAS No.: 81243-98-3
• Molecular Formula: C₄₇H₆₃N₅O₇Si₂
• Molecular Weight: 866.218

Synonyms:

Chemical Property of [(4-Methoxy-phenyl)-diphenyl-methyl]-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4-Methoxy-phenyl)-diphenyl-methyl]-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-amine

There total 4 articles about [(4-Methoxy-phenyl)-diphenyl-methyl]-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine (69304-45-6) → [(4-Methoxy-phenyl)-diphenyl-methyl]-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-amine (81243-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / triethylamine / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: p-toluenesulfonic acid / dioxane

With toluene-4-sulfonic acid; triethylamine; dmap; In 1,4-dioxane; dichloromethane;

DOI:10.1246/cl.1982.15

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → [(4-Methoxy-phenyl)-diphenyl-methyl]-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-amine (81243-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / triethylamine / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: p-toluenesulfonic acid / dioxane

With toluene-4-sulfonic acid; triethylamine; dmap; In 1,4-dioxane; dichloromethane;

DOI:10.1246/cl.1982.15

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → [(4-Methoxy-phenyl)-diphenyl-methyl]-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-amine (81243-98-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / pyridine

2: 96 percent / triethylamine / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: p-toluenesulfonic acid / dioxane

With pyridine; toluene-4-sulfonic acid; triethylamine; dmap; In 1,4-dioxane; dichloromethane;

DOI:10.1246/cl.1982.15

upstream raw materials:

3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

mono-4-methoxytrityl chloride

adenosine

Downstream raw materials:

Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

(2R,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-ol

Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

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