(+)-Saclofen

Base Information

Chemical Name:(+)-Saclofen
CAS No.:162894-55-5
Molecular Formula:C₉H₁₂ClNO₃S
Molecular Weight:249.718
Hs Code.:

Synonyms:

Suppliers and Price of (+)-Saclofen

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-Saclofen

Chemical Property:

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Technology Process of (+)-Saclofen

There total 3 articles about (+)-Saclofen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 134589-61-0
Sodium 2-(4-Chlorophenyl)-2-cyanoethylsulfonate

: 125464-42-8,162894-54-4,162894-55-5
(+)-Saclofen

Guidance literature:: With ammonium hydroxide; hydrogen; nickel; for 2h; under 2550.2 Torr; Ambient temperature;
DOI:10.1055/s-1991-26437

Reference yield:

: 27179-74-4
2-(4-Chlorophenyl)-2-propenenitrile

: 125464-42-8,162894-54-4,162894-55-5
(+)-Saclofen

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / NaHSO₃ / methanol; H₂O / 8 h / Heating

2: 59 percent / H₂, 6 percent aq. NH₃ / Raney Ni / 2 h / 2550.2 Torr / Ambient temperature

With ammonium hydroxide; hydrogen; sodium hydrogensulfite; nickel; In methanol; water;
DOI:10.1055/s-1991-26437

Reference yield:

: 114567-01-0
(E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile

: 125464-42-8,162894-54-4,162894-55-5
(+)-Saclofen

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaBH₃CN, AcOH, 2.) NaIO₄ / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) H₂O, r.t., 16 h

2: 71 percent / NaHSO₃ / methanol; H₂O / 8 h / Heating

3: 59 percent / H₂, 6 percent aq. NH₃ / Raney Ni / 2 h / 2550.2 Torr / Ambient temperature

With ammonium hydroxide; sodium periodate; hydrogen; sodium cyanoborohydride; sodium hydrogensulfite; acetic acid; nickel; In methanol; water;
DOI:10.1055/s-1991-26437