Proline, 1-benzoyl-, methyl ester

Base Information

• Chemical Name: Proline, 1-benzoyl-, methyl ester
• CAS No.: 114051-14-8
• Molecular Formula: C13H15NO3
• Molecular Weight: 233.267
• Mol file: 114051-14-8.mol

Synonyms:1-Benzoyl-pyrrolidine-2-carboxylic acid methyl ester;N-benzoylproline methyl ester;1-benzoyl-2-carboxymethylpyrrolidine;1-benzoyl-2-methoxycarbonylpyrrolidine;

Chemical Property of Proline, 1-benzoyl-, methyl ester

Chemical Property:

• PSA: 46.61000
• LogP: 1.40210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Proline, 1-benzoyl-, methyl ester

There total 6 articles about Proline, 1-benzoyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.4%

methanol (67-56-1) + N-benzoylproline (195719-48-3) → methyl 1-benzoylpyrrolidine-2-carboxylate (114051-14-8)

Guidance literature:

With thionyl chloride; at 10 - 20 ℃; Inert atmosphere;

Reference yield: 70.0%

methyl pyrrolidine-2-carboxylate hydrochloride (2133-40-6,65365-28-8,79397-50-5) + toluene (108-88-3,15644-74-3,16713-13-6) → methyl 1-benzoylpyrrolidine-2-carboxylate (114051-14-8)

Guidance literature:

With tert.-butylhydroperoxide; calcium carbonate; In dihydrogen peroxide; acetonitrile; at 80 ℃; for 10h; Catalytic behavior; Inert atmosphere;

DOI:10.1039/c7nj02257c

Reference yield:

L-proline methyl ester monohydrochloride (2133-40-6) + benzoyl chloride (98-88-4) → methyl 1-benzoylpyrrolidine-2-carboxylate (114051-14-8)

Guidance literature:

With triethylamine; In dichloromethane; water;

upstream raw materials:

diazomethane

benzoyl chloride

L-proline methyl ester monohydrochloride

methanol

Downstream raw materials:

[2-(hydroxymethyl)-1-pyrrolidinyl](phenyl)methanone

methyl 1-benzoyl-2-(nitrilomethyl)pyrrolidine-2-carboxylate

N-benzoyl-4-bromo-2-(methoxycarbonyl)pyrrole

N-benzoyl-3-bromo-2-(methoxycarbonyl)pyrrole