3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile

Base Information

• Chemical Name: 3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile
• CAS No.: 203512-84-9
• Molecular Formula: C₂₉H₃₂BrN₃O₃S
• Molecular Weight: 582.561

Synonyms:

Chemical Property of 3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile

There total 4 articles about 3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-cyano-phenyl)-acrylic acid methyl ester (193151-10-9) → 3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile (203512-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / AlMe₃ / toluene

2: TFA / CH₂Cl₂

With trimethylaluminum; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1016/S0960-894X(99)00164-X

Reference yield:

N-(4-bromobenzyl)-N-(trimethylsilylmethyl)-amine (203512-40-7) → 3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile (203512-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O / 0 °C

2: TFA / CH₂Cl₂

With water; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(99)00164-X

Reference yield:

(2R)-bornane-10,2-sultam (94594-90-8,124224-04-0) → 3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile (203512-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / AlMe₃ / toluene

2: TFA / CH₂Cl₂

With trimethylaluminum; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1016/S0960-894X(99)00164-X

upstream raw materials:

N-(4-bromobenzyl)-N-(trimethylsilylmethyl)aminomethyl methyl ether

3-[(E)-3-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-oxo-propenyl]-benzonitrile

3-(3-cyano-phenyl)-acrylic acid methyl ester

N-(4-bromobenzyl)-N-(trimethylsilylmethyl)-amine

Downstream raw materials:

(3S,4R)-1-[(2'-tert-butylaminosulfonyl-[1,1']-biphenyl-4-yl)methyl]-4-(3-cyanophenyl)pyrrolidin-3-ylcarboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 203512-84-9 3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send