C₁₅H₁₆F₃NO₃

Base Information

Chemical Name:C₁₅H₁₆F₃NO₃
CAS No.:1422252-53-6
Molecular Formula:C₁₅H₁₆F₃NO₃
Molecular Weight:315.292
Hs Code.:

C<sub>15</sub>H<sub>16</sub>F<sub>3</sub>NO<sub>3</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₅H₁₆F₃NO₃

Chemical Property:

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Technology Process of C₁₅H₁₆F₃NO₃

There total 4 articles about C₁₅H₁₆F₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.4%

: 1204331-63-4
4-(1-acetylpiperidin-4-yl)-3-(trifluoromethyl)methylbenzoate

: 50-01-1
guanidine hydrochloride

: 1422252-53-6
C₁₅H₁₆F₃NO₃

: 1422252-54-7
C₃₁H₃₃F₆N₅O₄

: 1204329-34-9
4-(1-acetylpiperidin-4-yl)-N-(diaminomethylene)-3-(trifluoromethyl)benzamide

Guidance literature:: guanidine hydrochloride; With 1-methyl-pyrrolidin-2-one; sodium tert-pentoxide; at 10 - 25 ℃; Large scale;

4-(1-acetylpiperidin-4-yl)-3-(trifluoromethyl)methylbenzoate; at 20 - 25 ℃; for 3h; Large scale;
DOI:10.1021/op300331b

Reference yield:

: 110-86-1
pyridine

: 1422252-53-6
C₁₅H₁₆F₃NO₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 20 - 30 °C / Large scale

1.2: 0.33 h / 20 - 25 °C / Large scale

1.3: 3.33 h / -5 - 25 °C / Large scale

2.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 - 55 °C / 10343.2 Torr / Inert atmosphere; Large scale

3.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic acid / methanol; dichloromethane / Large scale

4.1: triethylamine / methanol / 258.58 Torr / Inert atmosphere; Large scale

4.2: 20 h / 90 - 92 °C / 5171.62 Torr / Inert atmosphere; Large scale

5.1: 1-methyl-pyrrolidin-2-one; sodium tert-pentoxide / 10 - 25 °C / Large scale

5.2: 3 h / 20 - 25 °C / Large scale

With 1-methyl-pyrrolidin-2-one; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; palladium 10% on activated carbon; hydrogen; isopropylmagnesium bromide; sodium tert-pentoxide; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/op300331b

Reference yield:

: 1422252-48-9
1-(4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)ethanone

: 1422252-53-6
C₁₅H₁₆F₃NO₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic acid / methanol; dichloromethane / Large scale

2.1: triethylamine / methanol / 258.58 Torr / Inert atmosphere; Large scale

2.2: 20 h / 90 - 92 °C / 5171.62 Torr / Inert atmosphere; Large scale

3.1: 1-methyl-pyrrolidin-2-one; sodium tert-pentoxide / 10 - 25 °C / Large scale

3.2: 3 h / 20 - 25 °C / Large scale

With 1-methyl-pyrrolidin-2-one; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium tert-pentoxide; acetic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1021/op300331b