3-(2-NAPHTHYLTHIO)PROPIONIC ACID

Base Information

• Chemical Name: 3-(2-NAPHTHYLTHIO)PROPIONIC ACID
• CAS No.: 1141-45-3
• Molecular Formula: C13H12O2S
• Molecular Weight: 232.303
• Hs Code.: 2930909090
• Mol file: 1141-45-3.mol

Synonyms:3-(2-Naphthylthio)propionic acid;3-(naphthalen-2-ylthio)propanoic acid;3-(2-Naphthylsulfanyl)propanoic acid;3-(naphthalen-2-ylsulfanyl)-propanoic acid;3-[2]naphthylsulfanyl-propionic acid;3-[2]Naphthylmercapto-propionsaeure;3-(2-naphthylthio)propanoic acid;

Chemical Property of 3-(2-NAPHTHYLTHIO)PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 1.53E-08mmHg at 25°C
• Melting Point: 104-106oC
• Boiling Point: 440.6oC at 760 mmHg
• Flash Point: 220.3oC
• PSA: 62.60000
• Density: 1.27g/cm3
• LogP: 3.40660

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Naphthylthio)propionicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-NAPHTHYLTHIO)PROPIONIC ACID

There total 7 articles about 3-(2-NAPHTHYLTHIO)PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acrylic acid (79-10-7) + 2-Naphthalenethiol (91-60-1) → 3-(naphthalen-2-ylsulfanyl)-propanoic acid (1141-45-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; for 0.5h;

DOI:10.1016/j.tet.2007.11.064

Reference yield: 86.0%

chloropropionic acid (107-94-8) + 2-Naphthalenethiol (91-60-1) → 3-(naphthalen-2-ylsulfanyl)-propanoic acid (1141-45-3)

Guidance literature:

With sodium hydroxide; In methanol; water;

Reference yield: 83.0%

3-Bromopropionic acid (590-92-1) + 2-Naphthalenethiol (91-60-1) → 3-(naphthalen-2-ylsulfanyl)-propanoic acid (1141-45-3)

Guidance literature:

2-Naphthalenethiol; With sodium hydroxide; In water; Cooling with ice;

3-Bromopropionic acid; With sodium carbonate; In water; Cooling with ice; Reflux;

DOI:10.1021/ml200299g

upstream raw materials:

acrylic acid methyl ester

2-Naphthalenethiol

chloropropionic acid

acrylic acid

Downstream raw materials:

3-{1-[3-(2-Naphthylthio)propionyl]-piperidin-4-yl}-benzylamine trifluoroacetate

2-naphthylsulfonylpropionic acid

Refernces

• 1、 Bass, Shekinah A.,Parker, Dynasty M.,Bellinger, Tania J.,Eaton, Aireal S.,Dibble, Angelica S.,Koroma, Kaata L.,Sekyi, Sylvia A.,Pollard, David A.,Guo, Fenghai. "Development of conjugate addition of lithium dialkylcuprates to thiochromones: Synthesis of 2-alkylthiochroman-4-ones and additional synthetic applications". supporting information. . Retrieved 2018/08/21.
• 2、 Meng, Ling,Jin, Ming Yu,Wang, Jun. "Rh-Catalyzed Conjugate Addition of Arylzinc Chlorides to Thiochromones: A Highly Enantioselective Pathway for Accessing Chiral Thioflavanones". . p. 4986 - 4989. Retrieved 2016/10/14.