(1'S,2S)-N--2-hydroxymethylpyrrolidine

Base Information

Chemical Name:(1'S,2S)-N--2-hydroxymethylpyrrolidine
CAS No.:134295-61-7
Molecular Formula:C₁₆H₁₉NO₅S
Molecular Weight:337.397
Hs Code.:

(1'S,2S)-N-<o-(1'-(α-Furyl)-1'-hydroxymethyl)benzenesulfonyl>-2-hydroxymethylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'S,2S)-N--2-hydroxymethylpyrrolidine

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Technology Process of (1'S,2S)-N--2-hydroxymethylpyrrolidine

There total 3 articles about (1'S,2S)-N--2-hydroxymethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 134295-61-7
(1'S,2S)-N--2-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1a.) n-butyllithium, 1b.) Ti(O-iso-C₃H₇)4 / 1a.) THF, hexane, 0 deg C, 30 min, 1b.) 0 deg C, 30 min, 2.) 0 deg C, 3 h

With titanium(IV) isopropylate; n-butyllithium; triethylamine; In dichloromethane;
DOI:10.1248/cpb.39.260

Reference yield:

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 134295-61-7
(1'S,2S)-N--2-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1a.) n-butyllithium, 1b.) Ti(O-iso-C₃H₇)4 / 1a.) THF, hexane, 0 deg C, 30 min, 1b.) 0 deg C, 30 min, 2.) 0 deg C, 3 h

With titanium(IV) isopropylate; n-butyllithium; triethylamine; In dichloromethane;
DOI:10.1248/cpb.39.260

Reference yield:

: 98-01-1
furfural

: 122030-80-2
(S)-N-Benzenesulfonyl-2-hydroxymethylpyrrolidine

: 134295-62-8
(1'R,2S)-N--2-hydroxymethylpyrrolidine

: 134295-61-7
(1'S,2S)-N--2-hydroxymethylpyrrolidine

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, hexane, 0 deg C, 30 min, 2.) 0 deg C, 3 h;
DOI:10.1248/cpb.39.260