N-(2,2-DIMETHYLPROPANOYL)-4-FLUOROANILINE

Base Information

• Chemical Name: N-(2,2-DIMETHYLPROPANOYL)-4-FLUOROANILINE
• CAS No.: 114995-47-0
• Molecular Formula: C11H14FNO
• Molecular Weight: 195.237
• Hs Code.: 2924299090
• Mol file: 114995-47-0.mol

Synonyms:N-pivaloyl-4-fluoroaniline;N-pivaloyl-p-fluoroaniline;N-(4-fluorophenyl)pivalamide;N-(2,2-DIMETHYLPROPANOYL)-4-FLUOROANILINE;4-fluoro-N-pivaloylaniline;N-(4-fluorophenyl)-2,2-dimethylpropionamide;4-fluoropivalanilide;

Chemical Property of N-(2,2-DIMETHYLPROPANOYL)-4-FLUOROANILINE

Chemical Property:

• PSA: 29.10000
• LogP: 2.88330

Purity/Quality:

97% ^*data from raw suppliers

2,2-DIMETHYL-4'-FLUOROPROPIONANILIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,2-DIMETHYLPROPANOYL)-4-FLUOROANILINE

There total 5 articles about N-(2,2-DIMETHYLPROPANOYL)-4-FLUOROANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

pivaloyl chloride (3282-30-2) + 4-fluoroaniline (371-40-4) → N-(4-Fluorophenyl)-2,2-dimethylpropanamide (114995-47-0)

Guidance literature:

In chloroform; 1.) RT, 15 min, 2.) reflux, 3 h, 3.) RT, overnight;

DOI:10.1021/jo00250a019

Reference yield: 85.0%

N-pivaloylaniline (6625-74-7) → N-(4-Fluorophenyl)-2,2-dimethylpropanamide (114995-47-0)

Guidance literature:

With bis(tertbutylcarbonyloxy)iodobenzene; pyridine hydrogenfluoride; In dichloromethane; at 20 ℃; for 12h; Reagent/catalyst; regioselective reaction;

DOI:10.1021/jo302099d

Reference yield: 68.0%

2,2-dimethylpropanoic anhydride (1538-75-6) + 4-fluoroaniline (371-40-4) → N-(4-Fluorophenyl)-2,2-dimethylpropanamide (114995-47-0)

Guidance literature:

With triethylamine; In ethyl acetate; at 80 ℃; Inert atmosphere; Sealed tube;

DOI:10.1039/c3cc41331d

upstream raw materials:

pivaloyl chloride

4-fluoroaniline

N-(4-iodophenyl)pivalamide

N-pivaloylaniline

Downstream raw materials:

2-pivalamido-5-fluorophenyl-4'-pyridylcarbinol

N-(4-Fluoro-3-trimethylsilanyl-phenyl)-2,2-dimethyl-propionamide

N-(4-fluoro-2-methylphenyl)pivalamide

3-Methyl-6-fluoroquinoline