Methyl 3-ethoxy-5-hydroxybenzoate

Base Information

• Chemical Name: Methyl 3-ethoxy-5-hydroxybenzoate
• CAS No.: 116169-07-4
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Hs Code.: 2918990090
• Mol file: 116169-07-4.mol

Synonyms:3-ethoxy-5-hydroxy-benzoic acid methyl ester;Benzoic acid,3-ethoxy-5-hydroxy-,methyl ester;

Chemical Property of Methyl 3-ethoxy-5-hydroxybenzoate

Chemical Property:

• Boiling Point: 339.7±22.0 °C(Predicted)
• PKA: 8.81±0.10(Predicted)
• PSA: 55.76000
• Density: 1.180±0.06 g/cm3(Predicted)
• LogP: 1.57750
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Methyl3-ethoxy-5-hydroxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-ethoxy-5-hydroxybenzoate

There total 2 articles about Methyl 3-ethoxy-5-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-carbomethoxy-3,5-dihydroxybenzene (2150-44-9) + ethyl iodide (75-03-6) → methyl 3-ethoxy-5-hydroxybenzoate (116169-07-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.bmc.2009.02.038

Reference yield:

ethyl bromide (74-96-4) + 1-carbomethoxy-3,5-dihydroxybenzene (2150-44-9) → methyl 3-ethoxy-5-hydroxybenzoate (116169-07-4) + 3,5-diethoxybenzoic acid methyl ester (198623-55-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield: 91.0%

methyl 3-ethoxy-5-hydroxybenzoate (116169-07-4) + 1-fluoro-2-(methylsulfonyl)benzene (654-47-7) → methyl 3-ethoxy-5-[2-(methylsulfonyl)phenoxy]-benzoate (1147012-22-3)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 2h;

DOI:10.1016/j.bmc.2009.02.038

upstream raw materials:

1-carbomethoxy-3,5-dihydroxybenzene

ethyl iodide

ethyl bromide

Downstream raw materials:

3,5-diethoxybenzoic acid methyl ester

3-ethoxy-5-(tetrahydro-pyran-4-yloxy)-benzoic acid methyl ester

3-ethoxy-5-(2,2,2-trifluoro-ethoxy)-benzoic acid methyl ester

methyl 3-ethoxy-5-[2-(methylsulfonyl)phenoxy]-benzoate

Refernces

• 1、 Iino, Tomoharu,Tsukahara, Daisuke,Kamata, Kenji,Sasaki, Kaori,Ohyama, Sumika,Hosaka, Hideka,Hasegawa, Takuro,Chiba, Masato,Nagata, Yasufumi,Eiki, Jun-ichi,Nishimura, Teruyuki. "Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators". experimental part. p. 2733 - 2743. Retrieved 2009/09/08.
• 2、 -. "ASPARTYL PROTEASE INHIBITORS". Page 194-196. . Retrieved 2010/02/05.