1,4-bis(4-methoxybenzoyl)piperazine

Base Information

• Chemical Name: 1,4-bis(4-methoxybenzoyl)piperazine
• CAS No.: 116435-87-1
• Molecular Formula: C20H22N2O4
• Molecular Weight: 354.406
• Mol file: 116435-87-1.mol

Synonyms:1,4-Bis-(4-methoxy-benzoyl)-piperazin;1,4-BIS(4-METHOXYBENZOYL)PIPERAZINE;

Chemical Property of 1,4-bis(4-methoxybenzoyl)piperazine

Chemical Property:

• PSA: 59.08000
• LogP: 2.17780

Purity/Quality:

99% ^*data from raw suppliers

Piperazine-1,4-diylbis((4-methoxyphenyl)methanone) 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-bis(4-methoxybenzoyl)piperazine

There total 3 articles about 1,4-bis(4-methoxybenzoyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

piperazine (110-85-0) + 4-methoxy-benzoyl chloride (100-07-2) → piperazine-1,4-diylbis((4-methoxyphenyl)methanone) (116435-87-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.ejmech.2017.10.026

Reference yield: 45.0%

piperazine (110-85-0) + 4-methoxy-benzaldehyde (123-11-5) → piperazine-1,4-diylbis((4-methoxyphenyl)methanone) (116435-87-1)

Guidance literature:

piperazine; With C₅₆H₈₆F₂Li₂N₃O₄Si₂Sm; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere; Glovebox;

4-methoxy-benzaldehyde; In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere; Glovebox;

DOI:10.1039/c5ra20285j

Reference yield:

piperazine (110-85-0) + 4-methoxy-benzoyl chloride (100-07-2) → piperazine-1,4-diylbis((4-methoxyphenyl)methanone) (116435-87-1) + (4?methoxyphenyl)(piperazin?1?yl)methanone (94747-49-6)

Guidance literature:

In ethanol; at 0 - 20 ℃;

DOI:10.1039/C8RA09152H

upstream raw materials:

piperazine

4-methoxy-benzoyl chloride

4-methoxy-benzaldehyde

Refernces

• 1、 Petty, Aaron,Idippily, Nethrie,Bobba, Viharika,Geldenhuys, Werner J.,Zhong, Bo,Su, Bin,Wang, Bingcheng. "Design and synthesis of small molecule agonists of EphA2 receptor". . p. 1261 - 1276. Retrieved 2017/11/27.
• 2、 Wang, Chao,Huang, Lingling,Lu, Min,Zhao, Bei,Wang, Yaorong,Zhang, Yong,Shen, Qi,Yao, Yingming. "Anionic phenoxy-amido rare-earth complexes as efficient catalysts for amidation of aldehydes with amines". . p. 94768 - 94775. Retrieved 2015/11/24.