19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate

Base Information

• Chemical Name: 19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate
• CAS No.: 104494-67-9
• Molecular Formula: C₂₉H₄₆O₅Si
• Molecular Weight: 502.767
• Mol file: 104494-67-9.mol

Synonyms:

Chemical Property of 19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate

There total 1 articles about 19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lead(IV) tetraacetate (546-67-8) + 19-t-butyldimethylsilyloxy-3-(N-pyrrolidinyl)-pregna-3,5-dien-20-one (104494-66-8) → 19,21-dihydroxypregn-4-ene-3,20-dione 21-acetate (6901-40-2) + 19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate (104494-67-9)

Guidance literature:

With boron trifluoride diethyl etherate; sodium hydrogencarbonate; Yield given. Multistep reaction. Yields of byproduct given; 1.) MeOH-benzene, 4 h, room temp., 2.) aq. EtOH, 2 h, room temp.;

DOI:10.1016/S0040-4020(01)87452-4

Reference yield: 69.7%

19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate (104494-67-9) → 19,21-dihydroxypregn-4-ene-3,20-dione 21-acetate (6901-40-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87452-4

Reference yield:

19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate (104494-67-9) → 19,21-dihydroxypregn-4-ene-3,20-dione (2394-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 69.7 percent / n-Bu₄NF / tetrahydrofuran / 4 h / Ambient temperature

2: 73.4 percent / K₂CO₃ / methanol; H₂O / 4 h / Ambient temperature

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; methanol; water;

DOI:10.1016/S0040-4020(01)87452-4

upstream raw materials:

lead(IV) tetraacetate

19-t-butyldimethylsilyloxy-3-(N-pyrrolidinyl)-pregna-3,5-dien-20-one

Downstream raw materials:

19,21-dihydroxypregn-4-ene-3,20-dione 21-acetate

19-oxo-deoxycorticosterone

19-oxo-11-deoxycorticosterone acetate

19-Nordeoxycorticosterone