2394-23-2

Basic information

• Product Name: 19-hydroxydeoxycorticosterone
• Synonyms: 19,21-Dihydroxypregn-4-ene-3,20-dione;19-Hydroxy-11-deoxycorticosterone;19-Hydroxydesoxycorticosterone
• CAS NO: 2394-23-2
• Molecular Formula: C₂₁H₃₀O₄
• Molecular Weight: 346.46
• Mol File: 2394-23-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 538.7°Cat760mmHg
• Flash Point: 293.7°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 7.46E-14mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 19-hydroxydeoxycorticosterone(CAS DataBase Reference)
• NIST Chemistry Reference: 19-hydroxydeoxycorticosterone(2394-23-2)
• EPA Substance Registry System: 19-hydroxydeoxycorticosterone(2394-23-2)

Safety Data

• Hazardous Substances Data: 2394-23-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H30O4/c1-20-8-7-17-15(16(20)4-5-18(20)19(25)11-22)3-2-13-10-14(24)6-9-21(13,17)12-23/h10,15-18,22-23H,2-9,11-12H2,1H3/t15-,16-,17-,18+,20-,21+/m0/s1

Upstream product

• 26360-40-7 3β-acetoxy-19-hydroxy-Δ5-pregnen-20-one 
• 2857-42-3 3β-acetoxy-19-hydroxyandrost-5-en-17-one 
• 640-87-9 cortexolone 21-acetate 
• 19357-45-0 17α,21-dihydroxy-4-pregnene-3,20-dione 17-acetate 
• 152-58-9 Cortexolone 
• 104494-72-6 t-butyl 3β-t-butyldimethylsilyloxy-19-(2-tetrahydropyranyloxy)-20-methoxypregna-5,17(20)-dien-21-oate 
• 104494-70-4 methyl 3β-t-butyldimethylsilyloxy-19-(2-tetrahidropyranyloxy)-20-methoxypregna-5,17(20)-dien-21-oate 
• 104494-74-8 2-[(3S,8S,9S,10S,13S,14S)-3-(tert-Butyl-dimethyl-silanyloxy)-13-methyl-10-(tetrahydro-pyran-2-yloxymethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-2-methoxy-ethanol 
• 104494-67-9 19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate 
• 104494-76-0 Acetic acid 2-[(3S,8S,9S,10S,13S,14S)-3-hydroxy-13-methyl-10-(tetrahydro-pyran-2-yloxymethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-2-methoxy-ethyl ester 
• 104494-69-1 3β-t-butyldimethylsilyloxy-19-(2-tetrahydropyranyloxy)-androst-5-en-17-one 
• 104494-66-8 19-t-butyldimethylsilyloxy-3-(N-pyrrolidinyl)-pregna-3,5-dien-20-one 
• 104494-65-7 19-t-butyldimethylsilyloxyprogesterone 
• 104494-64-6 1-[(3S,8S,9S,10S,13S,14S,17S)-10-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone 

Downstream Products

• 116928-58-6 19,21-bis-benzoyloxy-11β-hydroxy-pregn-4-ene-3,20-dione 

Relevant articles and documents

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19 Hydroxylated cortisone derivative and preparation method 19 - hydroxyl androstenedione (by machine translation)

The invention discloses 19 hydroxylated cortisone derivatives and a preparation method, namely 19 - hydroxyandrostenedione. Belong to organic synthesis and pharmacy field. To the invention, 19 - hydroxyl group can be used as a raw material, 19 - hydroxyl can be supported in a plurality of groups under the action of hydrogen peroxide, trimethyl iodosilane, palladium carbon, dichloro dicyanobenzene quinone, iodobenzene, sodium borohydride, sodium periodate and the like respectively. 19 - hydroxyl can be supported to 19 - respectively. B ring can be supported by structural modification 17. 21 And/or 19-position hydroxyl groups are substituted; cleavage 19 - hydroxyl groups may support many loose side chains. The preparation method of the essential intermediate 19 - hydroxyandrostenedione synthesized by the norethindrone contraceptive is greatly improved, and the drug production cost. (by machine translation)

New Syntheses of 19,21-Dihydropregn-4-ene-3,20-dione, 21-Hydroxy-19-norpregn-4-ene-3,20-dione, and 11β,19,21-trihydroxypregn-4-ene-3,20-dione

19,21-Dihydroxypregn-4-ene-3,20-dione has been synthesized from 3β-acetoxypregn-5-en-20-one via the "hypoiodite reaction" , and Henbest acetoxylation at C-21; oxidation of the intermediate 21-monoacetate to 19-oxo derivative and alkaline cleavage gave 21-hydroxy-19-norpregn-4-ene-3,20-dione.A similar synthesis of 11β,19,21-trihydroxypregn-4-ene-3,20-dione from 3β-acetoxypregn-5-ene-11,20-dione proceeded through intermediates with the 11β-hydroxy function protected as its acetate.Unusual features mainly of conformational origin were observed in the presence of the 11β-acetoxy substituent; some were helpful to the synthesis, while others led to undesirable side reactions.