[3H]-BRL 52537

Base Information

• Chemical Name: [3H]-BRL 52537
• CAS No.: 128103-41-3
• Molecular Formula: C₁₈H₂₄Cl₂N₂O
• Molecular Weight: 355.307
• Mol file: 128103-41-3.mol

Synonyms:

Chemical Property of [3H]-BRL 52537

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3H]-BRL 52537

There total 9 articles about [3H]-BRL 52537 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

pyrrolidine (123-75-1) + 1-<(3,4-dichlorophenyl)acetyl>-2-piperidinecarboxaldehyde (125348-92-7) → [3H]-BRL 52537 (128103-41-3,130497-33-5,130497-34-6,130497-35-7)

Guidance literature:

With hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In methanol; for 72h; Ambient temperature;

DOI:10.1021/jm00081a009

Reference yield:

2-[(1-Pyrrolidinyl)methyl]piperidine (100158-63-2) + 2-(3,4-dichlorophenyl)acetyl chloride (6831-55-6) → [3H]-BRL 52537 (128103-41-3,130497-33-5,130497-34-6,130497-35-7)

Guidance literature:

With potassium carbonate; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jm00105a061

Reference yield:

3,4-dichlorophenyl acetic acid (5807-30-7) → [3H]-BRL 52537 (128103-41-3,130497-33-5,130497-34-6,130497-35-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 20 min, 2.) acetonitrile, RT, 6 h

2: 69 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: 76 percent / 5N HCl, 3-Angstroem molecular sieves, NaBH₃CN / methanol / 72 h / Ambient temperature

With pyridine; chromium(VI) oxide; hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; 1,1'-carbonyldiimidazole; In methanol; dichloromethane;

DOI:10.1021/jm00081a009

upstream raw materials:

pyrrolidine

1-<(3,4-dichlorophenyl)acetyl>-2-piperidinecarboxaldehyde

2-[(1-Pyrrolidinyl)methyl]piperidine

2-(3,4-dichlorophenyl)acetyl chloride

Refernces

• 1、 Vecchietti,Giordani,Giardina,Colle,Clarke. "(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: Novel, highly selective κ opioid analgesics". . p. 397 - 403. Retrieved 2007/10/02.