Phenoxy-acetic acid (2R,3S,5R)-5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-chloromethoxymethyl-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Phenoxy-acetic acid (2R,3S,5R)-5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-chloromethoxymethyl-tetrahydro-furan-3-yl ester
• CAS No.: 146961-98-0
• Molecular Formula: C₂₆H₂₆ClN₃O₇
• Molecular Weight: 527.961
• Mol file: 146961-98-0.mol

Synonyms:

Chemical Property of Phenoxy-acetic acid (2R,3S,5R)-5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-chloromethoxymethyl-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenoxy-acetic acid (2R,3S,5R)-5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-chloromethoxymethyl-tetrahydro-furan-3-yl ester

There total 4 articles about Phenoxy-acetic acid (2R,3S,5R)-5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-chloromethoxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-deoxy-N4-benzoyl-5-methylcytidine (104579-03-5) → Phenoxy-acetic acid (2R,3S,5R)-5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-chloromethoxymethyl-tetrahydro-furan-3-yl ester (146961-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / to r. t., 18 h

2: p-toluenesulfonic acid / methanol; CH₂Cl₂ / 0.5 h

3: 1) HCl(g) / CH₂Cl₂ / 1) 0 deg C, 10 min, 2) 4 deg C, 48 h

With pyridine; hydrogenchloride; toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1021/jo00063a014

Reference yield:

Phenoxyacetyl chloride (701-99-5) → Phenoxy-acetic acid (2R,3S,5R)-5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-chloromethoxymethyl-tetrahydro-furan-3-yl ester (146961-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / to r. t., 18 h

2: p-toluenesulfonic acid / methanol; CH₂Cl₂ / 0.5 h

3: 1) HCl(g) / CH₂Cl₂ / 1) 0 deg C, 10 min, 2) 4 deg C, 48 h

With pyridine; hydrogenchloride; toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1021/jo00063a014

Reference yield:

Phenoxy-acetic acid (2R,3S,5R)-5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (1053703-48-2) → Phenoxy-acetic acid (2R,3S,5R)-5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-chloromethoxymethyl-tetrahydro-furan-3-yl ester (146961-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / methanol; CH₂Cl₂ / 0.5 h

2: 1) HCl(g) / CH₂Cl₂ / 1) 0 deg C, 10 min, 2) 4 deg C, 48 h

With hydrogenchloride; toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1021/jo00063a014

upstream raw materials:

formaldehyd

N⁴-benzoyl-5-methyl-2'-deoxy-3'-O-(phenoxyacetyl)cytidine

5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-deoxy-N⁴-benzoyl-5-methylcytidine

Phenoxyacetyl chloride

Downstream raw materials:

C₅₇H₅₇N₅O₁₃S

C₄₉H₅₁N₅O₁₁S