Technology Process of 3-[4-(2-hydroxy-1,1-dimethyl-ethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester
There total 8 articles about 3-[4-(2-hydroxy-1,1-dimethyl-ethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 25 ℃;
DOI:10.1021/ml300175c
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 25 °C
2.1: tetrahydrofuran / 1 h / 0 °C
3.1: camphor-10-sulfonic acid / 1,4-dioxane / 75 °C / Sealed tube
3.2: 3 h / 75 - 80 °C / Sealed tube
4.1: sodium methylate / methanol / 72 h / 25 °C
5.1: 10% Pd/C; hydrogen / ethyl acetate / 25 °C
6.1: toluene / 6 h / 130 °C
7.1: potassium carbonate / methanol / 4 h / 85 °C
8.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 25 °C
With
camphor-10-sulfonic acid; 10% Pd/C; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml300175c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: camphor-10-sulfonic acid / 1,4-dioxane / 75 °C / Sealed tube
1.2: 3 h / 75 - 80 °C / Sealed tube
2.1: sodium methylate / methanol / 72 h / 25 °C
3.1: 10% Pd/C; hydrogen / ethyl acetate / 25 °C
4.1: toluene / 6 h / 130 °C
5.1: potassium carbonate / methanol / 4 h / 85 °C
6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 25 °C
With
camphor-10-sulfonic acid; 10% Pd/C; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml300175c
![3-(4-carboxy-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester](/Databaselist/images/loading.webp)
