2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-amide

Base Information

• Chemical Name: 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-amide
• CAS No.: 934422-73-8
• Molecular Formula: C₂₈H₂₈F₄N₆O
• Molecular Weight: 540.564
• Mol file: 934422-73-8.mol

Synonyms:

Chemical Property of 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-amide

There total 5 articles about 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester (543744-98-5) → 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-amide (934422-73-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH(OAc)3 / 1,2-dichloro-ethane

2: HCl / dioxane

3: Castro's reagent; NMM / dimethylformamide

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.11.071

Reference yield:

[1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-carbamic acid tert-butyl ester → 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-amide (934422-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / dioxane

2: Castro's reagent; NMM / dimethylformamide

With 4-methyl-morpholine; hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.11.071

Reference yield:

2-Fluorobenzaldehyde (446-52-6) → 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-amide (934422-73-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 49 percent / K₂CO₃ / dimethylsulfoxide / 85 °C

2: NaBH(OAc)3 / 1,2-dichloro-ethane

3: HCl / dioxane

4: Castro's reagent; NMM / dimethylformamide

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In 1,4-dioxane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.11.071

upstream raw materials:

1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-ylamine

[1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester

2-Fluorobenzaldehyde