543744-98-5Relevant academic research and scientific papers
Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues
Qiao, Jennifer X.,Cheng, Xuhong,Smallheer, Joanne M.,Galemmo, Robert A.,Drummond, Spencer,Pinto, Donald J.P.,Cheney, Daniel L.,He, Kan,Wong, Pancras C.,Luettgen, Joseph M.,Knabb, Robert M.,Wexler, Ruth R.,Lam, Patrick Y.S.
, p. 1432 - 1437 (2007)
The synthesis, SAR, pharmacokinetic profile, and modeling studies of both monocyclic and fused pyrazoles containing substituted N-arylpiperidinyl P4 moieties that are potent and selective factor Xa inhibitors will be discussed. Fused pyrazole analog 16a,
Substituted amino methyl factor Xa inhibitors
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, (2008/06/13)
The present application describes substituted-aminomethyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
