4-(1H-IMIDAZOL-2-YL)-PYRIDINE

Base Information

• Chemical Name: 4-(1H-IMIDAZOL-2-YL)-PYRIDINE
• CAS No.: 21202-42-6
• Molecular Formula: C8H7N3
• Molecular Weight: 145.164
• Hs Code.: 2933990090
• Mol file: 21202-42-6.mol

Synonyms:Pyridine,4-imidazol-2-yl- (8CI);2-(4-Pyridyl)imidazole;4-(1H-Imidazol-2-yl)pyridine;4-Imidazol-2-ylpyridine;NSC 245206;

Chemical Property of 4-(1H-IMIDAZOL-2-YL)-PYRIDINE

Chemical Property:

• Vapor Pressure: 4.3E-06mmHg at 25°C
• Melting Point: 210-211 °C(Solv: water (7732-18-5))
• Refractive Index: 1.61
• Boiling Point: 395.1°C at 760mmHg
• PKA: 11.50±0.10(Predicted)
• Flash Point: 198.7°C
• PSA: 41.57000
• Density: 1.214 g/cm³
• LogP: 1.47170
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-(1H-imidazol-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1H-IMIDAZOL-2-YL)-PYRIDINE

There total 7 articles about 4-(1H-IMIDAZOL-2-YL)-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(2-imidazolin-2-yl)pyridine (21381-61-3) → 4-(1H-imidazol-2-yl)pyridine (21202-42-6)

Guidance literature:

With potassium permanganate; silica gel; In acetonitrile; at 20 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2004.09.139

Reference yield: 77.0%

pyridine-4-carbonitrile (100-48-1) + aminopropane diethyl acetal (41365-75-7) → 4-(1H-imidazol-2-yl)pyridine (21202-42-6)

Guidance literature:

pyridine-4-carbonitrile; With sodium methylate; In methanol; at 20 ℃; for 8h;

aminopropane diethyl acetal; In methanol; acetic acid; for 0.5h; Reflux;

With hydrogenchloride; In methanol; water; acetic acid; for 3h; Reflux;

DOI:10.1039/c2nj40669a

Reference yield: 20.0%

pyridine-4-carbaldehyde (872-85-5) + Glyoxal (131543-46-9,107-22-2) → 4-(1H-imidazol-2-yl)pyridine (21202-42-6)

Guidance literature:

With ammonium hydroxide; In ethanol; water; for 6h; Heating;

DOI:10.1021/jo00180a021

upstream raw materials:

pyridine

2-Diazo-2H-imidazole

pyridine-4-carbaldehyde

Glyoxal

Downstream raw materials:

4-(4-(trifluoromethyl)-1H-imidazol-2-yl)pyridine