5-BENZO[1,3]DIOXOL-5-YL-2H-TETRAZOLE

Base Information

• Chemical Name: 5-BENZO[1,3]DIOXOL-5-YL-2H-TETRAZOLE
• CAS No.: 118923-32-3
• Molecular Formula: C8H6N4O2
• Molecular Weight: 190.161
• Mol file: 118923-32-3.mol

Synonyms:5-Benzo[1,3]dioxol-5-yl-1H-tetrazole;5-Benzo[1,3]dioxol-5-yl-1H-tetrazol;5-(benzo[1,3]dioxol-5yl)-1H-tetrazole;

Chemical Property of 5-BENZO[1,3]DIOXOL-5-YL-2H-TETRAZOLE

Chemical Property:

• PSA: 72.92000
• LogP: 0.59540

Purity/Quality:

99% ^*data from raw suppliers

5-BENZO[1,3]DIOXOL-5-YL-2H-TETRAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-BENZO[1,3]DIOXOL-5-YL-2H-TETRAZOLE

There total 9 articles about 5-BENZO[1,3]DIOXOL-5-YL-2H-TETRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

piperonylonitrile (4421-09-4) → 5-(benzo[d][1,3]dioxol-5-yl)-2H-tetrazole (118923-32-3)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 150 ℃; for 24h;

Reference yield: 85.0%

piperonylonitrile (4421-09-4) → 5-[3',4'-(methylenedioxy)benzen-1'-yl]-1H-tetrazole (118923-32-3)

Guidance literature:

With sodium azide; zinc dibromide; In water; isopropyl alcohol; for 24h; Reflux;

DOI:10.1016/j.ejmech.2013.11.008

Reference yield:

(E)-3,4-methylenedioxybenzaldehyde oxime (2089-36-3,20747-41-5,20747-42-6) → 5-[3',4'-(methylenedioxy)benzen-1'-yl]-1H-tetrazole (118923-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride / Reflux

2: sodium azide; zinc dibromide / water; isopropyl alcohol / 24 h / Reflux

With sodium azide; acetic anhydride; zinc dibromide; In water; isopropyl alcohol;

DOI:10.1016/j.ejmech.2011.12.033

upstream raw materials:

piperonylonitrile

piperonal

(E)-3,4-methylenedioxybenzaldehyde oxime

5-iodo-1,3-benzodioxole

Downstream raw materials:

5-(1,3-benzodioxol-5-yl)-1-[(4-isopropylphenyl)sulfonyl]-1H-tetrazole

5-(1,3-benzodioxol-5-yl)-1-[(2,4-dichlorophenyl)sulfonyl]-1H-tetrazole

5-(1,3-benzodioxol-5-yl)-1-[(4-chlorophenyl)sulfonyl]-1H-tetrazole

5-(1,3-benzodioxol-5-yl)-1-(phenylsulfonyl)-1H-tetrazole

Refernces

• 1、 Kobayashi, Eiji,Togo, Hideo. "Facile one-pot preparation of 5-aryltetrazoles and 3-arylisoxazoles from aryl bromides". . p. 4226 - 4235. Retrieved 2018/07/06.
• 2、 Dockendorff, Chris,Faloon, Patrick W.,Germain, Andrew,Yu, Miao,Youngsaye, Willmen,Nag, Partha P.,Bennion, Melissa,Penman, Marsha,Nieland, Thomas J.F.,Dandapani, Sivaraman,Perez, José R.,Munoz, Benito,Palmer, Michelle A.,Schreiber, Stuart L.,Krieger, Monty. "Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake". supporting information. p. 2594 - 2598. Retrieved 2015/06/02.