1-Chloro-4-(methoxymethyl)benzene

Base Information

• Chemical Name: 1-Chloro-4-(methoxymethyl)benzene
• CAS No.: 1195-44-4
• Molecular Formula: C8H9ClO
• Molecular Weight: 156.612
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID60475174
• Nikkaji Number: J345.095C
• Wikidata: Q82305475
• Mol file: 1195-44-4.mol

Synonyms:1-chloro-4-(methoxymethyl)benzene;1195-44-4;Benzene, 1-chloro-4-(methoxymethyl)-;p-chlorobenzyl methyl ether;4-chlorobenzyl methyl ether;Methyl 4-chlorobenzyl ether;SCHEMBL31273;SCHEMBL2357432;SCHEMBL10205408;DTXSID60475174;YOZIDEHIYNEGMS-UHFFFAOYSA-N;BAA19544;MFCD22054452;AKOS022173124;AM86383;BS-50044;CS-0182615;N10137

Chemical Property of 1-Chloro-4-(methoxymethyl)benzene

Chemical Property:

• PSA: 9.23000
• LogP: 2.48640
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 156.0341926
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Chloro-4-(methoxymethyl)benzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1=CC=C(C=C1)Cl

Technology Process of 1-Chloro-4-(methoxymethyl)benzene

There total 27 articles about 1-Chloro-4-(methoxymethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

para-Chlorobenzyl alcohol (873-76-7) + methyl iodide (74-88-4) → 4-chlorobenzyl methyl ether (1195-44-4)

Guidance literature:

para-Chlorobenzyl alcohol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c7gc03741d

Reference yield: 90.0%

(dimethoxy)methylsilane (16881-77-9) + 4-chlorobenzaldehyde (104-88-1) → 4-chlorobenzyl methyl ether (1195-44-4)

Guidance literature:

(dimethoxy)methylsilane; 4-chlorobenzaldehyde; With dicarbonyl(pentamethylcyclopentadienyl)(4-methoxyphenyl)iron; In dichloromethane; for 4h; Inert atmosphere; Irradiation; Schlenk technique;

With sodium hydroxide; In methanol; water; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2012.07.038

Reference yield: 90.0%

methanol (67-56-1) + 4-chlorobenzyl bromide (622-95-7) → 4-chlorobenzyl methyl ether (1195-44-4)

Guidance literature:

With iron(II) sulfate; at 75 ℃; for 12h;

DOI:10.1080/00397911003642674

upstream raw materials:

sodium methylate

1-Chloro-4-(chloromethyl)benzene

4-chlorophenylacetic Acid

methanol

Downstream raw materials:

d,l-1,2-bis-(4'-chlorophenyl)-1,2-dimethoxyethane

1,2-dimethoxy-1,2-di(4-chlorophenyl)ethane

Methyl 4-chlorobenzoate

para-chlorobenzoic acid