6-(3-Phenoxypropyl)-2,3-dihydro-1-benzofuran-5-ol

Base Information

Chemical Name:6-(3-Phenoxypropyl)-2,3-dihydro-1-benzofuran-5-ol
CAS No.:119794-95-5
Molecular Formula:C17H18O3
Molecular Weight:270.328
Hs Code.:
ChEMBL ID:CHEMBL266053
DSSTox Substance ID:DTXSID40560875
Wikidata:Q82444499
Mol file:119794-95-5.mol

Synonyms:119794-95-5;6-(3-phenoxypropyl)-2,3-dihydrobenzofuran-5-ol;6-(3-Phenoxypropyl)-2,3-dihydro-1-benzofuran-5-ol;CHEMBL266053;SCHEMBL10459597;DTXSID40560875

Suppliers and Price of 6-(3-Phenoxypropyl)-2,3-dihydro-1-benzofuran-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(3-Phenoxypropyl)-2,3-dihydro-1-benzofuran-5-ol

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:270.125594432
Heavy Atom Count:20
Complexity:288

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COC2=CC(=C(C=C21)O)CCCOC3=CC=CC=C3

Technology Process of 6-(3-Phenoxypropyl)-2,3-dihydro-1-benzofuran-5-ol

There total 11 articles about 6-(3-Phenoxypropyl)-2,3-dihydro-1-benzofuran-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 119795-53-8
5-Benzyloxy-6-(3-phenoxy-propyl)-2,3-dihydro-benzofuran

: 119794-95-5
2,3-dihydro-6-(3-phenoxypropyl)-5-benzofuranol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr;
DOI:10.1021/jm00125a014

Reference yield:

: 40492-52-2
2,3-dihydrobenzofuran-5-ol

: 119794-95-5
2,3-dihydro-6-(3-phenoxypropyl)-5-benzofuranol

Guidance literature:: Multi-step reaction with 2 steps

1: 76.9 percent / Br₂ / CH₂Cl₂ / Ambient temperature

2: 1) t-BuLi / 1) THF, hexane, -78 deg C, 10 min, 2) THF, r.t., 3 h

With bromine; tert.-butyl lithium; In dichloromethane;
DOI:10.1021/jm00125a014

Reference yield:

: 139-02-6
sodium phenoxide

: 119794-95-5
2,3-dihydro-6-(3-phenoxypropyl)-5-benzofuranol

Guidance literature:: Multi-step reaction with 2 steps

1: 0.210 g / dimethylformamide / 3 h / 80 °C

2: 52 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr

With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00125a014