N-(3-Chlorophenyl)-1-(phenylmethyl)-4-piperidinamine

Base Information

Chemical Name:N-(3-Chlorophenyl)-1-(phenylmethyl)-4-piperidinamine
CAS No.:115661-41-1
Molecular Formula:C₁₈H₂₁ClN₂
Molecular Weight:300.831
Hs Code.:
DSSTox Substance ID:DTXSID601217729

Synonyms:115661-41-1;N-(3-Chlorophenyl)-1-(phenylmethyl)-4-piperidinamine;DTXSID601217729;AKOS009181959

Suppliers and Price of N-(3-Chlorophenyl)-1-(phenylmethyl)-4-piperidinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-Chlorophenyl)-1-(phenylmethyl)-4-piperidinamine

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:300.1393264
Heavy Atom Count:21
Complexity:296

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1NC2=CC(=CC=C2)Cl)CC3=CC=CC=C3

Technology Process of N-(3-Chlorophenyl)-1-(phenylmethyl)-4-piperidinamine

There total 1 articles about N-(3-Chlorophenyl)-1-(phenylmethyl)-4-piperidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 108-42-9
3-chloro-aniline

: 115661-41-1
(1-Benzyl-piperidin-4-yl)-(3-chloro-phenyl)-amine

Guidance literature:: With sodium tetrahydroborate; toluene-4-sulfonic acid; Yield given. Multistep reaction; 1.) toluene, reflux, 48 h, 2.) methanol, room temperature, overnight;
DOI:10.1016/S0223-5234(97)82771-7

Reference yield: 85.0%

: 123-62-6
propionic acid anhydride

: 115661-41-1
(1-Benzyl-piperidin-4-yl)-(3-chloro-phenyl)-amine

: 202859-22-1
N-(1-benzylpiperidin-4-yl)-N-(3-chlorophenyl)propionamide

Guidance literature:: In toluene; Heating;
DOI:10.1016/S0223-5234(97)82771-7

Reference yield:

: 115661-41-1
(1-Benzyl-piperidin-4-yl)-(3-chloro-phenyl)-amine

: 202859-46-9
N-(3-chlorophenyl)-N-(piperidin-4-yl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / toluene / Heating

2: 1.) α-chloroethylchloroformiate, 2.) methanol / 1.) CH2Cl2, 0 deg C -> room temperature, 2.) 50 deg C, 1 h

With methanol; carbonochloridic acid 1-chloro-ethyl ester; In toluene;
DOI:10.1016/S0223-5234(97)82771-7