1,2-Propanediol, 3-(hexadecyloxy)-, 1-(4-methylbenzenesulfonate), (R)-

Base Information

• Chemical Name: 1,2-Propanediol, 3-(hexadecyloxy)-, 1-(4-methylbenzenesulfonate), (R)-
• CAS No.: 120019-37-6
• Molecular Formula: C26H46O5S
• Molecular Weight: 470.70500
• Mol file: 120019-37-6.mol

Synonyms:.1-O-hexadecyl-sn-glycerol 3-O-p-toluenesulfonate;(R)-1-O-hexadecyl-3-(p-toluenesulfonyl)-glycerol;.(R)-1-O-hexadecyl-3-(p-toluenesulfonyl)glycerol;

Chemical Property of 1,2-Propanediol, 3-(hexadecyloxy)-, 1-(4-methylbenzenesulfonate), (R)-

Chemical Property:

• PSA: 81.21000
• LogP: 7.63990

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Propanediol, 3-(hexadecyloxy)-, 1-(4-methylbenzenesulfonate), (R)-

There total 7 articles about 1,2-Propanediol, 3-(hexadecyloxy)-, 1-(4-methylbenzenesulfonate), (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

chimyl alcohol (506-03-6) + p-toluenesulfonyl chloride (98-59-9) → 3-hexadecyloxy-2R-hydroxypropyl 1-para-toluenesulphonate (120019-37-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 23 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c6md00328a

Reference yield: 44.0%

1-O-hexadecyl-2-O-hexadecanoyl-3-O-p-toluenesulfonylglycerol (146727-89-1) → 3-hexadecyloxy-2R-hydroxypropyl 1-para-toluenesulphonate (120019-37-6)

Guidance literature:

With water; In di-isopropyl ether; at 37 ℃; for 25h; 0.05 N phosphate buffer; Pseudomonas cepacia lipase on Celite;

DOI:10.1021/jo00057a015

Reference yield:

1-Hexadecanol (36653-82-4,124-29-8) + (S)-Glycidyl tosylate (70987-78-9,6746-81-2) → 3-hexadecyloxy-2R-hydroxypropyl 1-para-toluenesulphonate (120019-37-6) + 3‐hexadecyloxy‐2R‐hydroxyl propyl‐1‐p‐toluene sulphonate (119944-30-8)

Guidance literature:

boron trifluoride diethyl etherate; In chloroform; for 18h; Yield given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1021/ja00190a059

upstream raw materials:

1-Hexadecanol

(S)-Glycidyl tosylate

(R)-glycidyl tosylate

1-O-hexadecyl-2-O-hexadecanoyl-3-O-p-toluenesulfonylglycerol

Downstream raw materials:

L-1-hexadecyl-2-palmitoyl-phosphatidylcholine

diphenyl 1-O-hexadecyl-2-O-palmitoyl-sn-glycero-3-phosphate

diphenyl 1-O-hexadecyl-2-O-palmitoyl-sn-glycero-3-phosphate

1-O-hexadecyl-2-O-methyl-sn-glycero(3)phosphocholine