C₁₈H₂₇N₃O₄

Base Information

• Chemical Name: C₁₈H₂₇N₃O₄
• CAS No.: 1354899-38-9
• Molecular Formula: C₁₈H₂₇N₃O₄
• Molecular Weight: 349.43
• Mol file: 1354899-38-9.mol

Synonyms:

Chemical Property of C₁₈H₂₇N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₇N₃O₄

There total 8 articles about C₁₈H₂₇N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formic acid (64-18-6) + C24H33N3O3 → C18H27N3O4 (1354899-38-9)

Guidance literature:

formic acid; C₂₄H₃₃N₃O₃; With acetic anhydride; In dichloromethane; at 0 ℃;

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; under 760.051 Torr;

DOI:10.5012/bkcs.2011.32.6.2032

Reference yield:

(R)-2-hydroxymethyl-3-phenylpropionic acid (123802-80-2) → C18H27N3O4 (1354899-38-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 °C / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

3.2: pH 2.5

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

4.2: 20 °C

5.1: acetic anhydride / dichloromethane / 0 °C

5.2: 20 °C / 760.05 Torr

With 4-methyl-morpholine; dmap; acetic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; 2.1: Mitsunobu reaction;

DOI:10.5012/bkcs.2011.32.6.2032

Reference yield:

2R-benzyl-3-benzyloxypropanoic acid (123803-51-0) → C18H27N3O4 (1354899-38-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

4.2: pH 2.5

5.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

5.2: 20 °C

6.1: acetic anhydride / dichloromethane / 0 °C

6.2: 20 °C / 760.05 Torr

With 4-methyl-morpholine; dmap; palladium 10% on activated carbon; hydrogen; acetic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 3.1: Mitsunobu reaction;

DOI:10.5012/bkcs.2011.32.6.2032

upstream raw materials:

formic acid

(R)-2-hydroxymethyl-3-phenylpropionic acid

2R-benzyl-3-benzyloxypropanoic acid

(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionic acid