Bromo-PEG4-acid

Base Information

• Chemical Name: Bromo-PEG4-acid
• CAS No.: 1393330-38-5
• Molecular Formula: C₁₁H₂₁BrO₆
• Molecular Weight: 329.188
• Mol file: 1393330-38-5.mol

Synonyms:

Chemical Property of Bromo-PEG4-acid

Chemical Property:

• Boiling Point: 426.9±40.0 °C(Predicted)
• PKA: 4.28±0.10(Predicted)
• Density: 1.352±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

99.3% ^*data from raw suppliers

Bromo-PEG5-Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bromo-PEG4-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Technology Process of Bromo-PEG4-acid

There total 4 articles about Bromo-PEG4-acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl 1-bromo-3,6,9,12-tetraoxapentadecan-15-oate (564476-32-0) → C11H21BrO6 (1393330-38-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

Tetraethylene glycol (112-60-7) → C11H21BrO6 (1393330-38-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium / tetrahydrofuran / 20 h / 20 °C

2: triethylamine / dichloromethane / 6 h / 20 °C

3: lithium bromide / N,N-dimethyl-formamide / 1 h / 80 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With sodium; triethylamine; trifluoroacetic acid; lithium bromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 3-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)propanoate (518044-32-1,892154-71-1) → C11H21BrO6 (1393330-38-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 6 h / 20 °C

2: lithium bromide / N,N-dimethyl-formamide / 1 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With triethylamine; trifluoroacetic acid; lithium bromide; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

Tetraethylene glycol

tert-butyl 3-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)propanoate

tert-butyl 3-[2-(2-{2-[2-(toluene-4-sulfonyloxy)-ethoxy]ethoxy}ethoxy)ethoxy]propionate

tert-butyl 1-bromo-3,6,9,12-tetraoxapentadecan-15-oate