2-Bromo-1-(2-bromo-5-nitrophenyl)ethanone

Base Information

• Chemical Name: 2-Bromo-1-(2-bromo-5-nitrophenyl)ethanone
• CAS No.: 56759-35-4
• Molecular Formula: C₈H₅Br₂NO₃
• Molecular Weight: 322.941
• DSSTox Substance ID: DTXSID501272572
• Mol file: 56759-35-4.mol

Synonyms:2-Bromo-1-(2-bromo-5-nitrophenyl)ethanone;DTXSID501272572;56759-35-4

Chemical Property of 2-Bromo-1-(2-bromo-5-nitrophenyl)ethanone

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 322.86157
• Heavy Atom Count: 14
• Complexity: 241

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1[N+](=O)[O-])C(=O)CBr)Br

Technology Process of 2-Bromo-1-(2-bromo-5-nitrophenyl)ethanone

There total 4 articles about 2-Bromo-1-(2-bromo-5-nitrophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.8%

1-(2′-bromo-5′-nitrophenyl)ethan-1-one (65130-31-6) → 2-bromo-1-(2-bromo-5-nitro-phenyl)-ethanone (56759-35-4)

Guidance literature:

With copper(ll) bromide; In chloroform; ethyl acetate; for 5.5h; Reflux;

DOI:10.1016/j.tetlet.2009.12.070

Reference yield:

2-bromophenyl methyl ketone (2142-69-0) → 2-bromo-1-(2-bromo-5-nitro-phenyl)-ethanone (56759-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: fuming nitric acid / -3 - -1 °C

2: glacial acetic acid; bromine

With bromine; nitric acid; acetic acid;

Reference yield:

2-aminoacetophenone (551-93-9) → 2-bromo-1-(2-bromo-5-nitro-phenyl)-ethanone (56759-35-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; copper (I)-bromide / Diazotization

2: fuming nitric acid / -3 - -1 °C

3: glacial acetic acid; bromine

With sulfuric acid; bromine; nitric acid; acetic acid; copper(I) bromide;

upstream raw materials:

1-(2′-bromo-5′-nitrophenyl)ethan-1-one

2-bromophenyl methyl ketone

2-aminoacetophenone

Downstream raw materials:

2-bromo-1-(2-bromo-5-nitrophenyl)ethanone oxime