(1R,3R,4S)-p-menthan-3-yl hydrogen propylmalonate

Base Information

Chemical Name:(1R,3R,4S)-p-menthan-3-yl hydrogen propylmalonate
CAS No.:122778-23-8
Molecular Formula:C₁₆H₂₈O₄
Molecular Weight:284.396
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3R,4S)-p-menthan-3-yl hydrogen propylmalonate

Chemical Property:

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Technology Process of (1R,3R,4S)-p-menthan-3-yl hydrogen propylmalonate

There total 1 articles about (1R,3R,4S)-p-menthan-3-yl hydrogen propylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2216-51-5
(-)-menthol

: 616-62-6
n-propylmalonic acid

: 122778-23-8,122778-24-9
(1R,3R,4S)-p-menthan-3-yl hydrogen propylmalonate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile; -40 deg C, 6 h; room temperature, 10 h;

Reference yield:

: 122778-23-8,122778-24-9
(1R,3R,4S)-p-menthan-3-yl hydrogen propylmalonate

: 105-30-6,17092-41-0,17092-54-5,17092-42-1
(S)-2-methyl-1-pentanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH₂Cl₂, reflux, 2 h, 2.) -78 deg C, 30 min

2: 76.5 percent / Ph₃P, CCl₄ / 15 h / Heating

3: 95 percent / tributyltin hydride, AIBN / benzene / 10 h / Heating

4: di-isobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / -20 °C

With tetrachloromethane; oxalyl dichloride; diisobutylaluminum hydride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tetrabutylammonium borohydride; triphenylphosphine; In tetrahydrofuran; hexane; benzene;

Reference yield:

: 122778-23-8,122778-24-9
(1R,3R,4S)-p-menthan-3-yl hydrogen propylmalonate

: 122778-51-2
(S)-2-Methyl-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH₂Cl₂, reflux, 2 h, 2.) -78 deg C, 30 min

2: 76.5 percent / Ph₃P, CCl₄ / 15 h / Heating

3: 95 percent / tributyltin hydride, AIBN / benzene / 10 h / Heating

With tetrachloromethane; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tetrabutylammonium borohydride; triphenylphosphine; In benzene;